Bone morphogenetic proteins

T Katagiri, T Watabe - Cold Spring Harbor Perspectives …, 2016 - cshperspectives.cshlp.org
Bone morphogenetic proteins (BMPs), originally identified as osteoinductive components in
extracts derived from bone, are now known to play important roles in a wide array of …

Small-molecule based musculoskeletal regenerative engineering

KWH Lo, T Jiang, KA Gagnon, C Nelson… - Trends in …, 2014 - cell.com
Clinicians and scientists working in the field of regenerative engineering are actively
investigating a wide range of methods to promote musculoskeletal tissue regeneration …

BMP signaling in development and diseases: a pharmacological perspective

A Bandyopadhyay, PS Yadav, P Prashar - Biochemical pharmacology, 2013 - Elsevier
Bone morphogenetic protein (BMP) signaling has been implicated in several processes
during embryonic development and in adult tissue homeostasis. Maintenance of many …

Pharmacophore-based approaches in the rational repurposing technique for FDA approved drugs targeting SARS-CoV-2 M pro

VM Balaramnavar, K Ahmad, M Saeed, I Ahmad… - RSC …, 2020 - pubs.rsc.org
Novel coronavirus (CoV) is the primary etiological virus responsible for the pandemic that
started in Wuhan in 2019–2020. This viral disease is extremely prevalent and has spread …

Synthesis and evaluation of galloyl conjugates of flavanones as BMP-2 upregulators with promising bone anabolic and fracture healing properties

A Raj Pandey, D Rai, SP Singh… - Journal of Medicinal …, 2021 - ACS Publications
The molecular hybridization concept led us to design a series of galloyl conjugates of
flavanones that have potent osteoblast differentiation ability in vitro and promote bone …

Identification of novel PTP1B inhibitors by pharmacophore based virtual screening, scaffold hopping and docking

VM Balaramnavar, R Srivastava, N Rahuja… - European Journal of …, 2014 - Elsevier
Abstract Design and synthesis of protein tyrosine phosphatases-1B (PTP1B) inhibitors are
important for the drugs targeted to treat diabetes and obesity. The pharmacophore modeling …

Pharmacophore modeling, docking and the integrated use of a ligand-and structure-based virtual screening approach for novel DNA gyrase inhibitors: synthetic and …

D Mathpal, M Masand, A Thomas, I Ahmad, M Saeed… - RSC …, 2021 - pubs.rsc.org
Fluoroquinolones, a class of compound, act via inhibiting DNA gyrase and topoisomerase IV
enzymes. This is an important class of drugs with high success rates for the treatment of …

Developmental exposure to As, Cd, and Pb mixture diminishes skeletal growth and causes osteopenia at maturity via osteoblast and chondrocyte malfunctioning in …

S Abbas, K Khan, MP Khan, GK Nagar… - toxicological …, 2013 - academic.oup.com
We studied the effect of metal mixture (MM), comprising As, Cd, and Pb, in developing
female rat skeleton from gestation day 5 until postnatal day 60 (P-60). MM resulted in …

The twofold role of osteogenic small molecules in Parkinson's disease therapeutics: crosstalk of osteogenesis and neurogenesis

S Tavakol - BioMed research international, 2022 - Wiley Online Library
Deemed one of the most problematic neurodegenerative diseases in the elderly population,
Parkinson's disease remains incurable to date. Ongoing diagnostic studies, however, have …

Heartwood extract from Dalbergia sissoo promotes fracture healing and its application in ovariectomy-induced osteoporotic rats

A Karvande, V Khedgikar, P Kushwaha… - Journal of Pharmacy …, 2017 - academic.oup.com
Objectives This study was undertaken to investigate the effects of a heartwood ethanolic
extract (HEE) made from the Dalbergia sissoo on facture healing and in the prevention of …