As a result of the adaptation of life to an aerobic environment, nature has evolved a panoply
of metalloproteins for oxidative metabolism and protection against reactive oxygen species …

Cytochrome P450 (P450) enzymes are important in the metabolism of drugs, steroids, fat-
soluble vitamins, carcinogens, pesticides, and many other types of chemicals. Their catalytic …

Obesity is a major health risk still lacking effective pharmacological treatment. A potent anti-
obesity agent, celastrol, has been identified in the roots of Tripterygium wilfordii. However …

Enzymes are complex biological catalysts and are critical to life. Most oxidations of
chemicals are catalyzed by cytochrome P450 (P450, CYP) enzymes, which generally utilize …

Since our initial report in 1976, the oxygen rebound mechanism has become the consensus
mechanistic feature for an expanding variety of enzymatic C–H functionalization reactions …

Alkenes are among the most versatile building blocks and are widely used for the production
of polymers, detergents and synthetic lubricants. Currently, alkenes are sourced from …

Covering: 2000 up to 2018 The cytochromes P450 (P450s) are a superfamily of heme-
containing monooxygenases that perform diverse catalytic roles in many species, including …

The cytochromes P450 (P450s or CYPs) constitute a large heme enzyme superfamily,
members of which catalyze the oxidative transformation of a wide range of organic …

The photoenzymatic decarboxylation of fatty acids to alkanes is proposed as an alternative
approach for the synthesis of biodiesel. By using a recently discovered photodecarboxylase …

Understanding the molecular basis for controlled H2O2 activation is of fundamental
importance for peroxide-driven catalysis by metalloenzymes. In addition to O2 activation in …