Amyotrophic lateral sclerosis (ALS) is a neural disorder that causes death of the motor
neurons in the brain and spinal cord; this affects the voluntary muscles and gradually leads …

Mutations in the gene superoxide dismutase 1 (SOD1) are causative for familial forms of the
neurodegenerative disease amyotrophic lateral sclerosis. When the first SOD1 mutations …

Cu/Zn superoxide dismutase (SOD1) is a frontline antioxidant enzyme catalysing superoxide
breakdown and is important for most forms of eukaryotic life. The evolution of aerobic …

Oxidative stress is closely linked to the pathogenesis of neurodegeneration. Soluble amyloid
β (Aβ) oligomers cause cognitive impairment and synaptic dysfunction in Alzheimer disease …

TDP-43 inclusions are found in many Alzheimer's disease (AD) patients presenting faster
disease progression and greater brain atrophy. Previously, we showed full-length TDP-43 …

Alzheimer's disease (AD) is the most common age-related neurodegenerative disorder that
heavily burdens healthcare systems worldwide. There is a significant requirement to …

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by the
progressive demise of motor neurons. One of the causes of familial ALS is the mutation of …

Mitochondria provide energy to neurons through oxidative phosphorylation and eliminate
Reactive Oxygen Species (ROS) through Superoxide Dismutase 1 (SOD1). Dysfunctional …

Oxidative stress is an upsurge in reactive oxygen/nitrogen species (ROS/RNS), which
aggravates damage to cellular components viz. lipids, proteins, and nucleic acids resulting …

A variable-length poly-T variant in intron 6 of the TOMM40 gene, rs10524523, is associated
with risk and age-of-onset of sporadic (late-onset) Alzheimer's disease. In Caucasians, the …