Clinical update on head and neck cancer: molecular biology and ongoing challenges

E Alsahafi, K Begg, I Amelio, N Raulf, P Lucarelli… - Cell death & …, 2019 - nature.com
Head and neck squamous cell carcinomas (HNSCCs) are an aggressive, genetically
complex and difficult to treat group of cancers. In lieu of truly effective targeted therapies …

Novel systemic treatment modalities including immunotherapy and molecular targeted therapy for recurrent and metastatic head and neck squamous cell carcinoma

S Ghosh, PA Shah, FM Johnson - International journal of molecular …, 2022 - mdpi.com
Head and neck squamous cell carcinomas (HNSCCs) are the sixth most common cancers
worldwide. More than half of patients with HNSCC eventually experience disease …

YBX1 integration of oncogenic PI3K/mTOR signalling regulates the fitness of malignant epithelial cells

Y Bai, C Gotz, G Chincarini, Z Zhao, C Slaney… - Nature …, 2023 - nature.com
In heterogeneous head and neck cancer (HNC), subtype-specific treatment regimens are
currently missing. An integrated analysis of patient HNC subtypes using single-cell …

Precision medicine approaches to overcome resistance to therapy in head and neck cancers

S Ortiz-Cuaran, J Bouaoud, A Karabajakian… - Frontiers in …, 2021 - frontiersin.org
Head and neck squamous cell carcinoma (HNSCC) is the sixth most incident cancer
worldwide. More than half of HNSCC patients experience locoregional or distant relapse to …

Identification of potential biomarkers and survival analysis for head and neck squamous cell carcinoma using bioinformatics strategy: a study based on TCGA and …

Y Shen, J Liu, L Zhang, S Dong, J Zhang… - BioMed research …, 2019 - Wiley Online Library
The mechanism and gene markers of head and neck squamous cell carcinoma (HNSCC), a
common malignant tumor, have not yet been identified. The aim of this study was to identify …

γ‐Secretase inhibitor reduces immunosuppressive cells and enhances tumour immunity in head and neck squamous cell carcinoma

L Mao, ZL Zhao, GT Yu, L Wu, WW Deng… - … Journal of Cancer, 2018 - Wiley Online Library
Immune evasion is a hallmark feature of cancer, and it plays an important role in tumour
initiation and progression. In addition, tumour immune evasion severely hampers the …

Anti-CD47 treatment enhances anti-tumor T-cell immunity and improves immunosuppressive environment in head and neck squamous cell carcinoma

L Wu, GT Yu, WW Deng, L Mao, LL Yang, SR Ma… - …, 2018 - Taylor & Francis
Head and neck squamous cell carcinoma (HNSCC) is considered as an
immunosuppressive disease, with impaired tumor-infiltrating T lymphocytes and increased …

Drug-sensitivity screening and genomic characterization of 45 HPV-negative head and neck carcinoma cell lines for novel biomarkers of drug efficacy

T Lepikhova, PR Karhemo, R Louhimo, B Yadav… - Molecular cancer …, 2018 - AACR
There is an unmet need for effective targeted therapies for patients with advanced head and
neck squamous cell carcinoma (HNSCC). We correlated gene expression, gene copy …

Immunotherapy: The future of cancer treatment

M Sahu, H Suryawanshi - Journal of Oral and Maxillofacial …, 2021 - journals.lww.com
Head and neck squamous cell carcinomas (HNSCCs) are one of the most common cancers
worldwide. A large number of patients are diagnosed with locally advanced disease and …

Molecular pathways and targeted therapies in head and neck cancers pathogenesis

M Constantin, MC Chifiriuc, C Bleotu… - Frontiers in …, 2024 - pmc.ncbi.nlm.nih.gov
The substantial heterogeneity exhibited by head and neck cancer (HNC), encompassing
diverse cellular origins, anatomical locations, and etiological contributors, combined with the …