Immune cells and immunotherapy for cardiac injury and repair

JG Rurik, H Aghajanian, JA Epstein - Circulation research, 2021 - Am Heart Assoc
Cardiac injury remains a major cause of morbidity and mortality worldwide. Despite
significant advances, a full understanding of why the heart fails to fully recover function after …

Vascular remodelling in cardiovascular diseases: hypertension, oxidation, and inflammation

J Totoń-Żurańska, TP Mikolajczyk, B Saju… - Clinical …, 2024 - portlandpress.com
Optimal vascular structure and function are essential for maintaining the physiological
functions of the cardiovascular system. Vascular remodelling involves changes in vessel …

P2X3 receptor antagonism attenuates the progression of heart failure

RM Lataro, DJA Moraes, FN Gava, ACM Omoto… - Nature …, 2023 - nature.com
Despite advances in the treatment of heart failure, prognosis is poor, mortality high and there
remains no cure. Heart failure is associated with reduced cardiac pump function, autonomic …

What is the role of the inflammation in the pathogenesis of heart failure?

EC Castillo, E Vázquez-Garza, D Yee-Trejo… - Current Cardiology …, 2020 - Springer
Abstract Purpose of Review In heart failure, whether it is associated with reduced or
preserved ejection fraction, the immune system is activated and contributes to heart …

A cardioimmunologist's toolkit: genetic tools to dissect immune cells in cardiac disease

A Wong, H Hamidzada, S Epelman - Nature Reviews Cardiology, 2022 - nature.com
Cardioimmunology is a field that encompasses the immune cells and pathways that
modulate cardiac function in homeostasis and regulate the temporal balance between tissue …

The role of immune response in the pathogenesis of idiopathic pulmonary fibrosis: far beyond the Th1/Th2 imbalance

P Spagnolo, R Tonelli, AV Samarelli… - Expert Opinion on …, 2022 - Taylor & Francis
Introduction Idiopathic pulmonary fibrosis (IPF) is a chronic disease of unknown origin
characterized by progressive scarring of the lung leading to irreversible loss of function …

Ferroptosis in cardiovascular diseases: Role and mechanism

Q Zhang, Y Luo, L Peng, X Rong, Y Liu, J Li, J Luo - Cell & Bioscience, 2023 - Springer
In multicellular organisms, regulatory cell death is a crucial aspect of growth and
development. Ferroptosis, which was postulated roughly ten years ago, is a mode of cell …

Therapeutic applications of cannabinoids in cardiomyopathy and heart failure

JA Garza-Cervantes… - Oxidative Medicine …, 2020 - Wiley Online Library
A large number of cannabinoids have been discovered that could play a role in mitigating
cardiac affections. However, none of them has been as widely studied as cannabidiol …

[HTML][HTML] Inflammation and ischemic heart disease: The next therapeutic target?

EM Vilela, R Fontes-Carvalho - Revista Portuguesa de Cardiologia (English …, 2021 - Elsevier
Inflammation plays an important role in several stages of the cardiovascular continuum. In
recent decades a plethora of studies have provided new data highlighting the role of …

SWAP70 Overexpression Protects Against Pathological Cardiac Hypertrophy in a TAK1‐Dependent Manner

Q Qian, F Hu, W Yu, D Leng, Y Li, H Shi… - Journal of the …, 2023 - Am Heart Assoc
Background Pathological cardiac hypertrophy is regarded as a critical precursor and
independent risk factor of heart failure, and its inhibition prevents the progression of heart …