Autosomal dominant tubulointerstitial kidney disease
Autosomal dominant tubulointerstitial kidney disease (ADTKD) is a recently defined entity
that includes rare kidney diseases characterized by tubular damage and interstitial fibrosis …
that includes rare kidney diseases characterized by tubular damage and interstitial fibrosis …
The molecular functions of hepatocyte nuclear factors–In and beyond the liver
The hepatocyte nuclear factors (HNFs) namely HNF1α/β, FOXA1/2/3, HNF4α/γ and
ONECUT1/2 are expressed in a variety of tissues and organs, including the liver, pancreas …
ONECUT1/2 are expressed in a variety of tissues and organs, including the liver, pancreas …
Mitotic bookmarking redundancy by nuclear receptors in pluripotent cells
A Chervova, A Molliex, HI Baymaz, RX Coux… - Nature Structural & …, 2024 - nature.com
Mitotic bookmarking transcription factors (TFs) are thought to mediate rapid and accurate
reactivation after mitotic gene silencing. However, the loss of individual bookmarking TFs …
reactivation after mitotic gene silencing. However, the loss of individual bookmarking TFs …
[HTML][HTML] The rediscovery of uromodulin (Tamm–Horsfall protein): from tubulointerstitial nephropathy to chronic kidney disease
Uromodulin (Tamm–Horsfall protein) is the most abundant protein excreted in the urine
under physiological conditions. It is exclusively produced in the kidney and secreted into the …
under physiological conditions. It is exclusively produced in the kidney and secreted into the …
Bookmarking by specific and nonspecific binding of FoxA1 pioneer factor to mitotic chromosomes
While most transcription factors exit the chromatin during mitosis and the genome becomes
silent, a subset of factors remains and “bookmarks” genes for rapid reactivation as cells …
silent, a subset of factors remains and “bookmarks” genes for rapid reactivation as cells …
Mitotic binding of Esrrb marks key regulatory regions of the pluripotency network
Pluripotent mouse embryonic stem cells maintain their identity throughout virtually infinite
cell divisions. This phenomenon, referred to as self-renewal, depends on a network of …
cell divisions. This phenomenon, referred to as self-renewal, depends on a network of …
[HTML][HTML] Diagnosis, management, and prognosis of HNF1B nephropathy in adulthood
S Faguer, S Decramer, N Chassaing… - Kidney international, 2011 - Elsevier
Mutations in HNF1B are responsible for a dominantly inherited disease with renal and
nonrenal consequences, including maturity-onset diabetes of the young (MODY) type 5 …
nonrenal consequences, including maturity-onset diabetes of the young (MODY) type 5 …
A changing paradigm of transcriptional memory propagation through mitosis
The highly reproducible inheritance of chromosomes during mitosis in mammalian cells
involves nuclear envelope breakdown, increased chromatin compaction, loss of long-range …
involves nuclear envelope breakdown, increased chromatin compaction, loss of long-range …
Mitotic bookmarking by transcription factors
S Kadauke, GA Blobel - Epigenetics & chromatin, 2013 - Springer
Mitosis is accompanied by dramatic changes in chromatin organization and nuclear
architecture. Transcription halts globally and most sequence-specific transcription factors …
architecture. Transcription halts globally and most sequence-specific transcription factors …
miR-17∼ 92 miRNA cluster promotes kidney cyst growth in polycystic kidney disease
Polycystic kidney disease (PKD), the most common genetic cause of chronic kidney failure,
is characterized by the presence of numerous, progressively enlarging fluid-filled cysts in the …
is characterized by the presence of numerous, progressively enlarging fluid-filled cysts in the …