The ubiquitously expressed serum‐and glucocorticoid‐inducible kinase‐1 (SGK1) is
genomically regulated by cell stress (including cell shrinkage) and several hormones …

Dr. Conn originally reported an increased risk of diabetes in patients with
hyperaldosteronism in the 1950s, although the mechanism remains unclear. Aldosterone …

The FA translocase cluster of differentiation 36 (CD36) facilitates FA uptake by the
myocardium, and its surface recruitment in cardiomyocytes is induced by insulin, AMP …

Small G proteins exist in eukaryotes from yeast to human and constitute the Ras superfamily
comprising more than 100 members. This superfamily is structurally classified into five …

In tissues which express the mineralocorticoid receptor (MR), aldosterone modulates the
expression of membrane targets such as the subunits of the epithelial Na+ channel, in …

The mineralocorticoid receptor (MR) belongs to the steroid hormone receptor family and
classically functions as a ligand-dependent transcription factor. It is involved in water …

Studies aiming at the elucidation of the genetic basis of rare monogenic forms of
hypertension have identified mutations in genes coding for the epithelial sodium channel …

Increased activity of transforming growth factor–β (TGF-β), which binds to and stimulates cell
surface receptors, contributes to cancer progression and fibrosis by driving epithelial cells …

14-3-3 proteins regulate the function and subcellular sorting of membrane proteins. Often,
14-3-3 binding to client proteins requires phosphorylation of the client, but the relevant …

The kidney plays a key role in the maintenance of Mg2+ homeostasis. Specifically, the distal
convoluted tubule (DCT) is instrumental in the fine-tuning of renal Mg2+ handling. In recent …