Declines in physical performance and cognition are commonly observed in older adults. The
geroscience paradigm posits that a set of processes and pathways shared among age …

Sarcopenia characterized by reduced skeletal muscle mass and decreased muscle strength
is increasing in prevalence globally. The pathophysiology of sarcopenia is related to various …

Little is known about brain aging or dementia in nonindustrialized environments that are
similar to how humans lived throughout evolutionary history. This paper examines brain …

Objective Abnormal blood lipid levels are common in bipolar disorder (BD) and correlate
with mood symptoms and neurocognition. However, studies have not examined the lipid …

Background: Modifiable vascular risk factors have been associated with late-life cognitive
impairment. The Life Simple 7 (LS7) score comprises seven cardiovascular health metrics …

Neurodegenerative, vascular, and dementia diseases are linked to dysregulations in
cholesterol metabolism. Dietary plant sterols, or phytosterols, may interfere to …

High density lipoproteins (HDLs) display pleiotropic functions such as anti-inflammatory,
antioxidant, anti-protease, and anti-apoptotic properties. These effects are mediated by four …

Triglyceride (TG) and atherogenic index of plasma (AIP) have been acknowledged to be risk
factors for vascular insults, but their impacts on the brain system remain elusive. To fill in …

Background Although previous research has substantiated lifestyle and cardiovascular-
related measures have some impact on cognitive function, studies focusing on the …

Objective: We investigated whether vascular risk factors (VRFs), assessed with Life's Simple
7 (LS7), are associated with the rate of cognitive decline in the years preceding a dementia …