Bcl11 transcription factors regulate cortical development and function

R Simon, C Wiegreffe, S Britsch - Frontiers in molecular neuroscience, 2020 - frontiersin.org
Transcription factors regulate multiple processes during brain development and in the adult
brain, from brain patterning to differentiation and maturation of highly specialized neurons as …

Single-cell multi-cohort dissection of the schizophrenia transcriptome

WB Ruzicka, S Mohammadi, JF Fullard… - Science, 2024 - science.org
The complexity and heterogeneity of schizophrenia have hindered mechanistic elucidation
and the development of more effective therapies. Here, we performed single-cell dissection …

Mutation update for the SATB2 gene

YA Zarate, KA Bosanko, AR Caffrey… - Human …, 2019 - Wiley Online Library
Abstract SATB2‐associated syndrome (SAS) is an autosomal dominant
neurodevelopmental disorder caused by alterations in the SATB2 gene. Here we present a …

Circular RNA circSATB2 promotes progression of non-small cell lung cancer cells

N Zhang, A Nan, L Chen, X Li, Y Jia, M Qiu, X Dai… - Molecular cancer, 2020 - Springer
Background Lung cancer has high morbidity and mortality worldwide with non-small cell
lung cancer (NSCLC) accounting for 85% of the cases. Therapies for lung cancer have …

A gene expression atlas for different kinds of stress in the mouse brain

T Flati, S Gioiosa, G Chillemi, A Mele, A Oliverio… - Scientific Data, 2020 - nature.com
Stressful experiences are part of everyday life and animals have evolved physiological and
behavioral responses aimed at coping with stress and maintaining homeostasis. However …

Placenta transcriptome profiling in intrauterine growth restriction (IUGR)

M Majewska, A Lipka, L Paukszto… - International journal of …, 2019 - mdpi.com
Intrauterine growth restriction (IUGR) is a serious pathological complication associated with
compromised fetal development during pregnancy. The aim of the study was to broaden …

Genome-scale transcriptional regulatory network models of psychiatric and neurodegenerative disorders

JR Pearl, C Colantuoni, DE Bergey, CC Funk… - Cell systems, 2019 - cell.com
Transcriptional regulatory changes in the developing and adult brain are prominent features
of brain diseases, but the involvement of specific transcription factors (TFs) remains poorly …

The role of PAX2 in neurodevelopment and disease

N Lv, Y Wang, M Zhao, L Dong… - … Disease and Treatment, 2021 - Taylor & Francis
In developmental biology, transcription factors are involved in regulating the process of
neural development, controlling the differentiation of nerve cells, and affecting the normal …

Regulation of hippocampal mossy fiber-CA3 synapse function by a Bcl11b/C1ql2/Nrxn3 (25b+) pathway

A Koumoundourou, M Rannap, E De Bruyckere… - Elife, 2024 - elifesciences.org
The transcription factor Bcl11b has been linked to neurodevelopmental and
neuropsychiatric disorders associated with synaptic dysfunction. Bcl11b is highly expressed …

[HTML][HTML] Synaptic plasticity in schizophrenia pathophysiology

K Zhang, P Liao, J Wen, Z Hu - IBRO neuroscience reports, 2023 - Elsevier
Schizophrenia is a severe neuropsychiatric syndrome with psychotic behavioral
abnormalities and marked cognitive deficits. It is widely accepted that genetic and …