Colorectal cancer (CRC), a leading cause of cancer-related death worldwide, evolves as a
result of the stepwise accumulation of a series of genetic and epigenetic alterations in the …

Colorectal cancer is a leading cause of cancer related deaths worldwide. One of the
hallmarks of cancer and a fundamental trait of virtually all gastrointestinal cancers is …

The recently discovered histone post-translational modification crotonylation connects
cellular metabolism to gene regulation. Its regulation and tissue-specific functions are poorly …

Histones are DNA‐binding basic proteins found in chromosomes. After the histone
translation, its amino tail undergoes various modifications, such as methylation, acetylation …

Intestinal microbiota is an element of the bacterial ecosystem in all mammalian organisms.
These microorganisms play a very important part in the development, functioning, and …

Every year more than 13 million deaths worldwide are due to environmental pollutants, and
approximately 24% of diseases are caused by environmental exposures that might be …

Increased risk of colorectal cancer (CRC) is associated with altered intestinal microbiota as
well as short‐chain fatty acids (SCFAs) reduction of output The energy source of colon cells …

Metabolites are intermediate products of cellular metabolism catalysed by various enzymes.
Metabolic remodelling, as a biochemical fingerprint of cancer cells, causes abnormal …

Colorectal cancer (CRC) develops through a multistage process that results from the
progressive accumulation of genetic mutations, and frequently as a result of mutations in the …

Unlike the genome, the epigenome can be modified and hence some epigenetic risk
markers have the potential to be reversed. Such modifications take place by means of drugs …