MicroRNAs (miRNAs) are endogenous non-coding small RNA molecules that can be
secreted into the circulation and exist in remarkably stable forms. Like intercellular miRNAs …

Lipid‐based nanoparticles (LBNPs) are currently the most promising vehicles for nucleic
acid drug (NAD) delivery. Although their clinical applications have achieved success, the …

99% of administered nanoparticles will accumulate and sequester in the liver after
administration into the body. This results in reduced delivery to the targeted diseased tissue …

MicroRNAs (miRNAs) are endogenously initiated, small non-coding RNAs and typically
regulate the expression of mRNAs in post transcriptional level either via translational …

Lipid nanoparticles (LNPs) are currently the most clinically advanced nonviral carriers for the
delivery of small interfering RNA (siRNA). Free siRNA molecules suffer from unfavorable …

Circulating microRNAs (miRNA) are relatively stable in plasma and are a new class of
disease biomarkers. Here we present evidence that high-density lipoprotein (HDL) …

In the past few years, the crucial role of different micro-RNAs (miRNAs) in the cardiovascular
system has been widely recognized. Recently, it was discovered that extracellular miRNAs …

One of the most important advances in biology has been the discovery that siRNA (small
interfering RNA) is able to regulate the expression of genes, by a phenomenon known as …

Effective and safe delivery of anticancer agents is among the major challenges in cancer
therapy. The majority of anticancer agents are toxic to normal cells, have poor bioavailability …

RNA-based therapies, and siRNAs in particular, have attractive therapeutic potential for
cancer treatment due to their ability to silence genes that are imperative for tumor …