The Earth turns on its axis every 24 h; almost all life on the planet has a mechanism—
circadian rhythmicity—to anticipate the daily changes caused by this rotation. The molecular …

The potential for ischemic preconditioning to reduce infarct size was first recognized more
than 30 years ago [180]. Despite extension of the concept to ischemic postcondition‑ing …

Clinical trials using adult stem cells to regenerate damaged heart tissue continue to this
day,, despite ongoing questions of efficacy and a lack of mechanistic understanding of the …

Extracellular vesicles (EVs)—particularly exosomes and microvesicles (MVs)—are attracting
considerable interest in the cardiovascular field as the wide range of their functions is …

A large number of clinical trials have shown stem cell therapy to be a promising therapeutic
approach for the treatment of cardiovascular diseases. Since the first transplantation into …

Ischaemic heart disease and the heart failure that often results, remain the leading causes of
death and disability in Europe and worldwide. As such, in order to prevent heart failure and …

We engineered a microneedle patch integrated with cardiac stromal cells (MN-CSCs) for
therapeutic heart regeneration after acute myocardial infarction (MI). To perform cell-based …

Aims A better understanding of the pathways that regulate regeneration of the coronary
vasculature is of fundamental importance for the advancement of strategies to treat patients …

The adult heart is a vital and highly specialized organ of the human body, with limited
capability of self-repair and regeneration in case of injury or disease. Engineering …

Successfully engineering a functional, human, myocardial pump would represent a
therapeutic alternative for the millions of patients with end-stage heart disease and provide …