Recent advances in biomimetic nanodelivery systems: new brain-targeting strategies

J Liao, L Fan, Y Li, QQ Xu, LY Xiong, SS Zhang… - Journal of Controlled …, 2023 - Elsevier
In recent years, brain diseases have seriously threatened human health due to their high
morbidity and mortality. Achieving efficient drug delivery to provide satisfactory therapeutic …

Nanomedicine progress in thrombolytic therapy

A Zenych, L Fournier, C Chauvierre - Biomaterials, 2020 - Elsevier
Thrombotic occlusions of blood vessels are responsible for life-threatening cardiovascular
disorders such as myocardial infarction, ischemic stroke, and venous thromboembolism …

Rescuing ischemic stroke by biomimetic nanovesicles through accelerated thrombolysis and sequential ischemia-reperfusion protection

W Yu, N Yin, Y Yang, C Xuan, X Liu, W Liu, Z Zhang… - Acta biomaterialia, 2022 - Elsevier
Rational design of nanomedicine to accelerate thrombolysis and sequentially avoid
thrombolysis-mediated reperfusion injury is still a challenge. Here, we develop a biomimetic …

Biomimetic fibrin-targeted and H2O2-responsive nanocarriers for thrombus therapy

Y Zhao, R Xie, N Yodsanit, M Ye, Y Wang, S Gong - Nano Today, 2020 - Elsevier
Thrombosis is a principle cause of various life-threatening cardiovascular diseases.
However, current antithrombotic treatments using drugs only offer limited efficacy due to …

Targeted inhibition of tumor inflammation and tumor-platelet crosstalk by nanoparticle-mediated drug delivery mitigates cancer metastasis

S Li, L Li, X Lin, C Chen, C Luo, Y Huang - ACS nano, 2021 - ACS Publications
Sowing malignant cells (the “seeds” of metastasis) to engraft secondary sites requires a
conducive premetastatic niche (PMN, the “soil” of metastasis). Inflammation and tumor …

Advanced drug delivery system against ischemic stroke

S Zhang, Y Zhou, R Li, Z Chen, X Fan - Journal of Controlled Release, 2022 - Elsevier
Ischemic stroke is a vascular central nervous system (CNS) disease that leads a disability
and death. Thrombolysis and neuroprotection are the primary treatment strategies of …

Antithrombotic Therapy by Regulating the ROS‐Mediated Thrombosis Microenvironment and Specific Nonpharmaceutical Thrombolysis Using Prussian Blue …

W Zhang, J Wang, Z Xie, H Zou, Q Chen, L Xu, L Hu… - Small, 2022 - Wiley Online Library
In thrombotic diseases, the effects of reactive oxygen species (ROS)‐mediated oxidative
stress as a “perpetrator” in thrombosis must be resolved. Accordingly, an insufficient …

Hemostatic nanotechnologies for external and internal hemorrhage management

L Wang, X You, C Dai, T Tong, J Wu - Biomaterials Science, 2020 - pubs.rsc.org
An uncontrolled hemorrhage can easily lead to death during surgery and military operations.
Despite the significant advances in hemostatic research, there is still an urgent and …

Near-infrared light-responsive liposomes for protein delivery: Towards bleeding-free photothermally-assisted thrombolysis

A Refaat, B Del Rosal, J Palasubramaniam… - Journal of Controlled …, 2021 - Elsevier
Smart drug delivery systems represent state-of-the-art approaches for targeted therapy of life-
threatening diseases such as cancer and cardiovascular diseases. Stimuli-responsive on …

Application of nanotechnology in thrombus therapy

S Zhou, W Zhao, J Hu, C Mao… - Advanced Healthcare …, 2023 - Wiley Online Library
A thrombus is a blood clot that forms in the lumen of an artery or vein, restricting blood flow
and causing clinical symptoms. Thrombosis is associated with many life‐threatening …