Combination chemotherapy regimens including irinotecan and oxaliplatin markedly improve
response rate and prolong median survival over fluorouracil with leucovorin (FU/LV), and …

Purpose: To provide a current review of the literature related to chemotherapy induced
diarrhea (CID), including clinical assessment, recommended management guidelines and …

Purpose This phase III study compared the safety and efficacy of the following three different
irinotecan-containing regimens in the first-line treatment of metastatic colorectal cancer …

Background The optimum use of cytotoxic drugs for advanced colorectal cancer has not
been defined. Our aim was to investigate whether combination treatment is better than …

Written by world-class experts in clinical cancer therapeutics, Physicians' Cancer
Chemotherapy Drug Manual 2017 provides a complete, easy-to-use catalog of over 100 …

Purpose The AIO KRK-0104 randomized phase II trial investigated the efficacy and safety of
cetuximab combined with capecitabine and irinotecan (CAPIRI) or capecitabine and …

Since its approval for the first-line treatment of metastatic colorectal cancer (mCRC),
bevacizumab has become a standard treatment option in combination with chemotherapy …

Purpose To compare clinical benefit response (CBR) and quality of life (QOL) in patients
receiving gemcitabine (Gem) plus capecitabine (Cap) versus single-agent Gem for …

Irinotecan is a topo-isomerase-I inhibitor with broad antitumor activity in solid tumors. Its use
may lead to severe toxicities, predominantly neutropenia and diarrhea which can be life …

Purpose To evaluate the clinical activity and toxicity of capecitabine plus irinotecan as first-
line therapy for patients with metastatic colorectal cancer (mCRC), and to describe the …