Under physiological conditions, adenosine triphosphate (ATP) is present at low levels in the
extracellular milieu, being massively released by stressed or dying cells. Once outside the …

The P2X7 receptor is a trimeric ATP-gated cation channel found predominantly, but not
exclusively, on immune cells. P2X7 activation results in a number of downstream events …

Although extracellular ATP is abundant at sites of inflammation, its role in activating
inflammasome signalling in neutrophils is not well characterized. In the current study, we …

The term uveitis encompasses a very diverse group of inflammatory ocular diseases that
cause a significant burden of legal and economic blindness. Indeed, the socioeconomic …

Ocular toxoplasmosis (OT) is considered the most frequent form of infectious posterior
uveitis and is caused by the protozoan parasite Toxoplasma gondii. The resulting vision loss …

Induction of immunity that limits Toxoplasma gondii infection in mice is critically dependent
on the activation of the innate immune response. In this study, we investigated the role of …

Abstract ATP-gated P2X receptors are trimeric ion channels that assemble as homo-or
heteromers from seven cloned subunits. Transcripts and/or proteins of P2X subunits have …

The intracellular protozoan Toxoplasma gondii is an exceptionally successful food and
waterborne parasite that infects approximately 1 billion people worldwide. Genotyping of T …

One third of humans are infected lifelong with the brain-dwelling, protozoan parasite,
Toxoplasma gondii. Approximately fifteen million of these have congenital toxoplasmosis …

Toxoplasma is a highly successful parasite that establishes a life-long chronic infection. To
do this, it must carefully regulate immune activation and host cell effector mechanisms. Here …