Obesity cardiomyopathy: evidence, mechanisms, and therapeutic implications

J Ren, NN Wu, S Wang, JR Sowers… - Physiological …, 2021 - journals.physiology.org
The prevalence of heart failure is on the rise and imposes a major health threat, in part, due
to the rapidly increased prevalence of overweight and obesity. To this point …

Prognostic role of inflammatory cytokines and novel adipokines in acute myocardial infarction: An updated and comprehensive review

A Mitsis, NPE Kadoglou, V Lambadiari, S Alexiou… - Cytokine, 2022 - Elsevier
Acute myocardial infarction (AMI) is one of the major causes of morbidity and mortality
worldwide. The inflammation response during and after AMI is common and seems to play a …

Epicardial adipose tissue density and volume are related to subclinical atherosclerosis, inflammation and major adverse cardiac events in asymptomatic subjects

M Goeller, S Achenbach, M Marwan, MK Doris… - Journal of …, 2018 - Elsevier
Background We investigated whether epicardial adipose tissue (EAT) volume and density
are related to early atherosclerosis, plaque inflammation and major adverse cardiac events …

[PDF][PDF] Clinical importance of epicardial adipose tissue

E Nagy, AL Jermendy, B Merkely… - Archives of Medical …, 2017 - termedia.pl
Different visceral fat compartments have several systemic effects and may play a role in the
development of both insulin resistance and cardiovascular diseases. In the last couple of …

A prospective randomized study comparing effects of empagliflozin to sitagliptin on cardiac fat accumulation, cardiac function, and cardiac metabolism in patients with …

S Hiruma, F Shigiyama, S Hisatake, S Mizumura… - Cardiovascular …, 2021 - Springer
Background While the cardioprotective benefits of sodium-glucose cotransporter-2 (SGLT2)
inhibitors have been established in patients with cardiovascular disease (CVD), their …

The role of adipocytokines in coronary atherosclerosis

L Liberale, A Bonaventura, A Vecchiè, C Matteo… - Current atherosclerosis …, 2017 - Springer
Abstract Purpose of Review The aim of this review is to overview the pathophysiological role
of adipocytokines in atherogenesis, focusing on their potential role as biomarkers of …

Epigenetics and obesity cardiomyopathy: from pathophysiology to prevention and management

Y Zhang, J Ren - Pharmacology & therapeutics, 2016 - Elsevier
Uncorrected obesity has been associated with cardiac hypertrophy and contractile
dysfunction. Several mechanisms for this cardiomyopathy have been identified, including …

The impact of chest CT body composition parameters on clinical outcomes in COVID-19 patients

G Besutti, M Pellegrini, M Ottone, M Cantini, J Milic… - PloS one, 2021 - journals.plos.org
We assessed the impact of chest CT body composition parameters on outcomes and
disease severity at hospital presentation of COVID-19 patients, focusing also on the possible …

Towards reference values of pericoronary adipose tissue attenuation: impact of coronary artery and tube voltage in coronary computed tomography angiography

R Ma, D Ties, M van Assen, GJ Pelgrim… - European …, 2020 - Springer
Objectives To determine normal pericoronary adipose tissue mean attenuation (PCAT MA)
values for left the anterior descending (LAD), left circumflex (LCX), and right coronary artery …

Adipose tissue‐derived plasminogen activator inhibitor‐1 function and regulation

H Kaji - Comprehensive Physiology, 2011 - Wiley Online Library
Adipose tissue has recently been reevaluated as an endocrine organ, and adipose‐tissue‐
derived endocrine factors are termed adipokines. Plasminogen activator inhibitor‐1 (PAI‐1) …