Kinases control a diverse set of cellular processes comprising of reversible phosphorylation
of proteins. Protein kinases play a pivotal role in human tumor cell proliferation, migration …

This review focuses on the syntheses of PI3K/Akt/mTOR inhibitors that have been reported
outside of the patent literature in the last 5years but is largely centered on synthetic work …

Novel purine-pyrazole hybrids combining thiazoles, thiazolidinones and rhodanines, were
designed and tested as 15-LOX inhibitors, potential anticancer and antioxidant agents. All …

Small N-heterocyclic molecules are important scaffolds in the pharmaceutical industry and
most FDA-approved drugs are nitrogen-containing heterocycles. Chemists try to employ iron …

Synthesis of C8N9 Annulated Purines by IronCatalyzed CH Amination Page 1 DOI: 10.1002/chem.201301248
Synthesis of C8ÀN9 Annulated Purines by Iron-Catalyzed CÀH Amination Jens Maes, Tom …

Aim: Targeting apoptosis regulators such as caspases aiming at inducing apoptosis is an
attractive strategy in cancer therapy. Materials & methods: 8-substituted purine incorporating …

Abstract Two series of N-(4-methoxyphenyl)-N-methyl-9H-purin-6-amines (9a-d and 10a-h)
and 9-substituted benzyl-6-chloro-9H-purines (11a-h) were designed and synthesized. Their …

PDK1, a biological target that has attracted a large amount of attention recently, is
responsible for the positive regulation of the PI3K/Akt pathway that is often activated in a …

''Inflammation''broadly describes a tissue response to insult. It may be pathological, or it may
be healthy and regenerative. 1 Therapeutic approaches to inflammation have tended to …

Chapter 13 360 become highly skilled in developing bespoke ATP competitive kinase
inhibitors, 1, 2 which achieve selectivity by targeting distinguishing features of their active …