Beige fat plays key roles in the regulation of systemic energy homeostasis; however,
detailed mechanisms and safe strategy for its activation remain elusive. In this study, we …

Exercise enhances physical performance and reduces the risk of many disorders such as
cardiovascular disease, type 2 diabetes, dementia, and cancer. Exercise characteristically …

Nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH) remain
without effective therapies. The mechanistic target of rapamycin complex 1 (mTORC1) …

Misalignment of feeding rhythms with the light-dark cycle leads to disrupted peripheral
circadian clocks and obesity. Conversely, restricting feeding to the active period mitigates …

Metabolism and aging are tightly connected. Alpha-ketoglutarate is a key metabolite in the
tricarboxylic acid (TCA) cycle, and its levels change upon fasting, exercise, and aging. Here …

Heart failure with preserved ejection fraction (HFpEF) is a highly prevalent and intractable
form of cardiac decompensation commonly associated with diastolic dysfunction. Here, we …

The anorexigenic peptide glucagon-like peptide-1 (GLP-1) is secreted from gut
enteroendocrine cells and brain preproglucagon (PPG) neurons, which, respectively, define …

Compelling evidence shows that brown and beige adipose tissue are protective against
metabolic diseases,. PR domain-containing 16 (PRDM16) is a dominant activator of the …

Brown and beige adipose tissue are emerging as distinct endocrine organs. These tissues
are functionally associated with skeletal muscle, adipose tissue metabolism and systemic …

Stimulation of adipose tissue thermogenesis is regarded as a promising avenue in the
treatment of obesity. However, pharmacologic engagement of this process has proven …