Recent advancements in stem cell technology open a new door for patients suffering from
diseases and disorders that have yet to be treated. Stem cell-based therapy, including …

Natural killer cells (NK cells) are innate immune cells that are activated to fight tumor cells
and virus-infected cells. NK cells also play an important role in the graft versus leukemia …

Abstract Plakophilin-2 (PKP2) is a key component of desmosomes, which, when defective, is
known to promote the fibro-fatty infiltration of heart muscle. Less attention has been given to …

Accumulation of lipid substances decreased the activity of osteoblasts. Trehalose is a typical
stress metabolite to form a protective membrane on cell surface which has been …

Arrhythmogenic Cardiomyopathy (ACM) is characterized by the replacement of the
myocardium with fibrotic or fibro-fatty tissue and inflammatory infiltrates in the heart. To date …

Abstract Three-dimensional (3D) cell cultivation systems in vitro are promising biomodels to
study the metabolic processes of healthy and diseased human heart cells. Cardiac 3D …

Arrhythmogenic cardiomyopathy (ACM) is hallmarked by ventricular fibro‐adipogenic
alterations, contributing to cardiac dysfunctions and arrhythmias. Although genetically …

Background Cardiac mesenchymal stromal cells (C-MSC) were recently shown to
differentiate into adipocytes and myofibroblasts to promote the aberrant remodeling of …

Nicotinic acid adenine dinucleotide phosphate (NAADP) is a newly discovered second
messenger that gates two pore channels 1 (TPC1) and 2 (TPC2) to elicit endo-lysosomal …

Hematopoietic stem cell transplantation (HSCT) is the ultimate choice of treatment for
patients with hematological diseases and cancer. The success of HSCT is critically …