[HTML][HTML] The progress of gut microbiome research related to brain disorders

S Zhu, Y Jiang, K Xu, M Cui, W Ye, G Zhao… - Journal of …, 2020 - Springer
There is increasing evidence showing that the dynamic changes in the gut microbiota can
alter brain physiology and behavior. Cognition was originally thought to be regulated only by …

[HTML][HTML] Advances in metagenomics and its application in environmental microorganisms

L Zhang, FX Chen, Z Zeng, M Xu, F Sun… - Frontiers in …, 2021 - frontiersin.org
Metagenomics is a new approach to study microorganisms obtained from a specific
environment by functional gene screening or sequencing analysis. Metagenomics studies …

[HTML][HTML] Personalized mapping of drug metabolism by the human gut microbiome

B Javdan, JG Lopez, P Chankhamjon, YCJ Lee, R Hull… - Cell, 2020 - cell.com
The human gut microbiome harbors hundreds of bacterial species with diverse biochemical
capabilities. Dozens of drugs have been shown to be metabolized by single isolates from …

Advances in ultrahigh-throughput screening for directed enzyme evolution

U Markel, KD Essani, V Besirlioglu, J Schiffels… - Chemical Society …, 2020 - pubs.rsc.org
Enzymes are versatile catalysts and their synthetic potential has been recognized for a long
time. In order to exploit their full potential, enzymes often need to be re-engineered or …

Platforms for antibiotic discovery

K Lewis - Nature reviews Drug discovery, 2013 - nature.com
The spread of resistant bacteria, leading to untreatable infections, is a major public health
threat but the pace of antibiotic discovery to combat these pathogens has slowed down …

[HTML][HTML] The road to metagenomics: from microbiology to DNA sequencing technologies and bioinformatics

A Escobar-Zepeda, A Vera-Ponce de León… - Frontiers in …, 2015 - frontiersin.org
The study of microorganisms that pervade each and every part of this planet has
encountered many challenges through time such as the discovery of unknown organisms …

Natural products in drug discovery

AL Harvey - Drug discovery today, 2008 - Elsevier
Natural products have been the single most productive source of leads for the development
of drugs. Over a 100 new products are in clinical development, particularly as anti-cancer …

Metagenomics: application of genomics to uncultured microorganisms

J Handelsman - Microbiology and molecular biology reviews, 2004 - Am Soc Microbiol
Metagenomics (also referred to as environmental and community genomics) is the genomic
analysis of microorganisms by direct extraction and cloning of DNA from an assemblage of …

Combating multidrug‐resistant bacteria: current strategies for the discovery of novel antibacterials

KMG O'Connell, JT Hodgkinson… - Angewandte Chemie …, 2013 - Wiley Online Library
The introduction of effective antibacterial therapies for infectious diseases in the mid‐20th
century completely revolutionized clinical practices and helped to facilitate the development …

[HTML][HTML] Bile acid 7α-dehydroxylating gut bacteria secrete antibiotics that inhibit Clostridium difficile: role of secondary bile acids

JD Kang, CJ Myers, SC Harris, G Kakiyama, IK Lee… - Cell chemical …, 2019 - cell.com
Clostridium scindens biotransforms primary bile acids into secondary bile acids, and is
correlated with inhibition of Clostridium difficile growth in vivo. The aim of the current study …