Smoking represents one of the most important preventable risk factors for the development
of atherosclerosis. The present review aims at providing a comprehensive summary of …

Background Exposure to cigarette smoke (CS) is a major threat to human health worldwide.
It is well established that smoking increases the risk of respiratory diseases, cardiovascular …

Until very recently addiction-research was limited by existing tools and strategies that were
inadequate for studying the inherent complexity at each of the different phenomenological …

Significance: Chronic obstructive pulmonary disease (COPD) is predominantly a tobacco
smoke-triggered disease with features of chronic low-grade systemic inflammation and …

Chronic obstructive pulmonary disease (COPD) is a debilitating respiratory disease and one
of the leading causes of morbidity and mortality worldwide. It is characterized by persistent …

The aim of this study is to provide a systematic review of the known epigenetic alterations
caused by cigarette smoke; establish an evidence-based perspective of their clinical value …

Idiopathic pulmonary fibrosis (IPF) is a chronic lung disease of high unmet medical need.
Although bromodomain (Brd) and extra terminal domain isoforms have recently been …

Disrupted daily or circadian rhythms of lung function and inflammatory responses are
common features of chronic airway diseases. At the molecular level these circadian rhythms …

Increased mortality and diverse morbidities are globally associated with exposure to
ambient air pollution (AAP), cigarette smoke (CS), and household air pollution (HAP). The …

Cigarette smoke (CS)-mediated oxidative stress induces several signaling cascades,
including kinases, which results in chromatin modifications (histone acetylation …