Metabotropic glutamate receptors and neurodegenerative diseases

FM Ribeiro, LB Vieira, RGW Pires, RP Olmo… - Pharmacological …, 2017 - Elsevier
Glutamate is the most important excitatory neurotransmitter of the mammalian central
nervous system (CNS), playing an important role in memory, synaptic plasticity and neuronal …

Pharmacological agents acting at subtypes of metabotropic glutamate receptors

DD Schoepp, DE Jane, JA Monn - Neuropharmacology, 1999 - Elsevier
Metabotropic (G-protein-coupled) glutamate (mGlu) receptors have now emerged as a
recognized, but still relatively new area of excitatory amino acid research. Current …

Structural, signalling and regulatory properties of the group I metabotropic glutamate receptors: prototypic family C G-protein-coupled receptors

E Hermans, RAJ CHALLISS - Biochemical Journal, 2001 - portlandpress.com
In 1991 a new type of G-protein-coupled receptor (GPCR) was cloned, the type 1a
metabotropic glutamate (mGlu) receptor, which, despite possessing the defining seven …

Astrocytes in neural circuits: key factors in synaptic regulation and potential targets for neurodevelopmental disorders

X Liu, J Ying, X Wang, Q Zheng, T Zhao… - Frontiers in Molecular …, 2021 - frontiersin.org
Astrocytes are the major glial cells in the brain, which play a supporting role in the energy
and nutritional supply of neurons. They were initially regarded as passive space-filling cells …

International union of basic and clinical pharmacology. CXI. Pharmacology, signaling, and physiology of metabotropic glutamate receptors

KJ Gregory, C Goudet, EH Ohlstein - Pharmacological reviews, 2021 - Elsevier
Metabotropic glutamate (mGlu) receptors respond to glutamate, the major excitatory
neurotransmitter in the mammalian brain, mediating a modulatory role that is critical for …

Structural aspects of phenylglycines, their biosynthesis and occurrence in peptide natural products

RS Al Toma, C Brieke, MJ Cryle… - Natural product reports, 2015 - pubs.rsc.org
Covering up to February 2015 Phenylglycine-type amino acids occur in a wide variety of
peptide natural products, including glycopeptide antibiotics and biologically active linear …

Lipid droplet biogenesis induced by stress involves triacylglycerol synthesis that depends on group VIA phospholipase A2

A Gubern, M Barcelo-Torns, J Casas, D Barneda… - Journal of biological …, 2009 - ASBMB
This work investigates the metabolic origin of triacylglycerol (TAG) formed during lipid
droplet (LD) biogenesis induced by stress. Cytotoxic inhibitors of fatty acid synthase induced …

Metabotropic glutamate receptors as targets for multipotential treatment of neurological disorders

KR Byrnes, DJ Loane, AI Faden - Neurotherapeutics, 2009 - Elsevier
Glutamate is a major excitatory neurotransmitter in the CNS that is involved in numerous
cellular functions, including cell death and survival. Metabotropic glutamate receptors …

Metabotropic glutamate receptors in glial cells

S D'Antoni, A Berretta, CM Bonaccorso, V Bruno… - Neurochemical …, 2008 - Springer
Glutamate is the major excitatory neurotransmitter in the mammalian central nervous system
(CNS) and exerts its actions via a number of ionotropic glutamate receptors/channels and …

Functions and pathophysiological roles of phospholipase D in the brain

J Klein - Journal of neurochemistry, 2005 - Wiley Online Library
Ten years after the isoforms of mammalian phospholipase D (PLD), PLD1 and 2, were
cloned, their roles in the brain remain speculative but several lines of evidence now …