From immunology to artificial intelligence: revolutionizing latent tuberculosis infection diagnosis with machine learning
LS Li, L Yang, L Zhuang, ZY Ye, WG Zhao… - Military Medical …, 2023 - Springer
Latent tuberculosis infection (LTBI) has become a major source of active tuberculosis (ATB).
Although the tuberculin skin test and interferon-gamma release assay can be used to …
Although the tuberculin skin test and interferon-gamma release assay can be used to …
Manipulation and Exploitation Of Host Immune System by Pathogenic Mycobacterium Tuberculosis for its Advantage
Mycobacterium tuberculosis (Mtb) can become a long-term infection by evading the host
immune response. Coevolution of Mtb with humans has resulted in its ability to hijack the …
immune response. Coevolution of Mtb with humans has resulted in its ability to hijack the …
Virtual screening, pharmacokinetics, molecular dynamics and binding free energy analysis for small natural molecules against cyclin-dependent kinase 5 for …
Alzheimer's disease (AD) is a progressive neurodegenerative disorder and characterized by
brain cell death, memory loss and is the most common form of dementia. Although AD has …
brain cell death, memory loss and is the most common form of dementia. Although AD has …
Identification of lead molecules against potential drug target protein MAPK4 from L. donovani: An in-silico approach using docking, molecular dynamics and binding …
Leishmaniasis caused by obligate intracellular parasites of genus Leishmania is one of the
most neglected tropical diseases threatening 350 million people worldwide. Protein kinases …
most neglected tropical diseases threatening 350 million people worldwide. Protein kinases …
In silico identification and validation of natural antiviral compounds as potential inhibitors of SARS-CoV-2 methyltransferase
The novel Coronavirus disease 2019 (COVID-19) is potentially fatal and caused by Severe
Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). Due to the unavailability of any …
Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). Due to the unavailability of any …
Identification of novel small molecules against GSK3β for Alzheimer's disease using chemoinformatics approach
Alzheimer's disease is a rapidly increasing neurodegenerative disease. It is a multifactorial
disease and also a global threat. Several enzymes are implicated in the disease in which …
disease and also a global threat. Several enzymes are implicated in the disease in which …
Repurposing of the herbal formulations: molecular docking and molecular dynamics simulation studies to validate the efficacy of phytocompounds against SARS-CoV …
Herbal formulations mentioned in traditional medicinal texts were investigated for in silico
effect against SARS-COV-2 proteins involved in various functions of a virus such as …
effect against SARS-COV-2 proteins involved in various functions of a virus such as …
Repurposing of drugs against methyltransferase as potential Zika virus therapies
In recent years, the outbreak of infectious disease caused by Zika Virus (ZIKV) has posed a
major threat to global public health, calling for the development of therapeutics to treat ZIKV …
major threat to global public health, calling for the development of therapeutics to treat ZIKV …
[HTML][HTML] High-throughput screening of natural compounds and inhibition of a major therapeutic target HsGSK-3β for Alzheimer's disease using computational …
Background Alzheimer's disease is a leading neurodegenerative disease worldwide and is
the 6th leading cause of death in the USA. AD is a very complex disease and the drugs …
the 6th leading cause of death in the USA. AD is a very complex disease and the drugs …
Mechanistic insights on nsSNPs on binding site of renin and cytochrome P450 proteins: A computational perceptual study for pharmacogenomics evaluation
L Loganathan, BB Kuriakose, S Mushfiq… - Journal of Cellular …, 2021 - Wiley Online Library
Past several decades, therapeutic investigations lead to the discovery of numerous
antihypertensive drugs. Although it has been proved for their potency, altered efficacy is …
antihypertensive drugs. Although it has been proved for their potency, altered efficacy is …