Advances in microbicide vaginal rings

RK Malcolm, KL Edwards, P Kiser, J Romano, TJ Smith - Antiviral research, 2010 - Elsevier
Vaginal ring devices capable of providing sustained/controlled release of incorporated
actives are already marketed for steroidal contraception and estrogen replacement therapy …

Microbicide vaginal rings: Technological challenges and clinical development

RK Malcolm, PJ Boyd, CF McCoy, DJ Murphy - Advanced drug delivery …, 2016 - Elsevier
Vaginal rings (VRs) are flexible, torus-shaped, polymeric devices designed to sustain
delivery of pharmaceutical drugs to the vagina for clinical benefit. Following first report in a …

Drug-eluting fibers for HIV-1 inhibition and contraception

C Ball, E Krogstad, T Chaowanachan, KA Woodrow - PloS one, 2012 - journals.plos.org
Multipurpose prevention technologies (MPTs) that simultaneously prevent sexually
transmitted infections (STIs) and unintended pregnancy are a global health priority …

Intravaginal rings as delivery systems for microbicides and multipurpose prevention technologies

AR Thurman, MR Clark, JA Hurlburt… - International journal of …, 2013 - Taylor & Francis
There is a renewed interest in delivering pharmaceutical products via intravaginal rings
(IVRs). IVRs are flexible torus-shaped drug delivery systems that can be easily inserted and …

Intravaginal ring delivery of the reverse transcriptase inhibitor TMC 120 as an HIV microbicide

AD Woolfson, RK Malcolm, RJ Morrow… - International journal of …, 2006 - Elsevier
TMC 120 (Dapivirine) is a potent non-nucleoside reverse transcriptase inhibitor that is
presently being developed as a vaginal HIV microbicide. To date, most vaginal microbicides …

Effectiveness of female controlled barrier methods in preventing sexually transmitted infections and HIV: current evidence and future research directions

AM Minnis, NS Padian - Sexually transmitted infections, 2005 - sti.bmj.com
Objectives: To evaluate evidence for the effectiveness of female controlled physical and
chemical barrier methods in preventing STI/HIV transmission, to examine recent reviews on …

Multipurpose prevention technologies: oral, parenteral, and vaginal dosage forms for prevention of HIV/STIs and unplanned pregnancy

IC Young, SR Benhabbour - Polymers, 2021 - mdpi.com
There is a high global prevalence of HIV, sexually transmitted infections (STIs), and
unplanned pregnancies. Current preventative daily oral dosing regimens can be ineffective …

A silicone elastomer vaginal ring for HIV prevention containing two microbicides with different mechanisms of action

SM Fetherston, P Boyd, CF McCoy, MC McBride… - European journal of …, 2013 - Elsevier
Vaginal rings are currently being developed for the long-term (at least 30days) continuous
delivery of microbicides against human immunodeficiency virus (HIV). Research to date has …

[PDF][PDF] Silicone polymers in controlled drug delivery systems: a review

A Mashak, A Rahimi - 2009 - sid.ir
In this paper some of the latest studies and research works conducted on SILICONE based
DRUG DELIVERY SYSTEMS (DDS) are reviewed and some of more specific and important …

Vaginal rings for delivery of HIV microbicides

RK Malcolm, SM Fetherston, CF McCoy… - … Journal of Women's …, 2012 - Taylor & Francis
Following the successful development of long-acting steroid-releasing vaginal ring devices
for the treatment of menopausal symptoms and contraception, there is now considerable …