Many drugs, or their antecedents, were discovered through observation of their effects on
normal or disease physiology. For the past generation, this phenotypic drug discovery …

Aberrant activation of the Wnt signaling pathway has been identified in numerous types of
cancer. One common feature of oncogenic Wnt regulation involves an increase in the …

Background Naringin is a naturally occurring flavanone that promotes osteogenesis. Owing
to the high lipophilicity, poor in vivo bioavailability, and extensive metabolic alteration upon …

The colchicine binding site in microtubules is the most flourishing target for anticancer
treatment. Microtubule inhibitor drugs, including paclitaxel and vinca alkaloids, have been …

In this issue of Cell Chemical Biology, Cheng et al.(2021) identify a class of drugs that
activate a mitotic stress-dependent signaling cascade, which culminates in p53 activation …