Physical activity is one of the modifiable factors of cognitive decline and dementia with the
strongest evidence. Although many influential reviews have illustrated the neurobiological …

OBJECTIVE: To present a conceptual model explaining the mechanisms for the effect of
physical activity on cognitive and mental health in young people and to conduct a systematic …

Significant progress has been made in understanding the neurobiological mechanisms
through which exercise protects and restores the brain. In this feature review, we integrate …

No medications prevent or reverse age-related cognitive decline. Physical activity (PA)
enhances memory in rodents, but findings are mixed in human studies. As a result, exercise …

Animal models point towards a key role of brain-derived neurotrophic factor (BDNF), insulin-
like growth factor-I (IGF-I) and vascular endothelial growth factor (VEGF) in mediating …

Physical activity has been known as an essential element to promote human health for
centuries. Thus, exercise intervention is encouraged to battle against sedentary lifestyle …

Brain-derived neurotrophic factor (BDNF) is a protein that stimulates processes of
neurogenesis, the survival of neurons and microglia, stimulates neuroplasticity, and takes …

Global concern on the potential impact of dementia is mounting. There are emerging calls
for studies in older populations to investigate the potential benefits of combining cognitive …

In the natural habitat of our ancestors, physical activity was not a preventive intervention but
a matter of survival. In this hostile environment with scarce food and ubiquitous dangers …

Physical activity or appropriate exercise prevents the development of osteoporosis.
However, the exact mechanism remains unclear although it is well accepted that exercise or …