Colorectal cancer (CRC) is one of the main causes of cancer death in the world. Post-
translational modifications (PTMs) have been extensively studied in malignancies due to its …

The pathogenesis of hepatocellular carcinoma (HCC) is a multistep process, involving the
progressive accumulation of molecular alterations and transcriptomic alterations. The …

Abstract CD4+ CD25+ FoxP3+ regulatory T cells (Tregs) are increased in patients with
chronic hepatitis C, which may contribute to the sustained suppression of hepatitis C virus …

O-GlcNAcylation is a reversible post-translational protein modification that regulates
fundamental cellular processes including immune responses and autoimmunity. Previously …

Hepatitis C virus (HCV) is a major cause of chronic liver diseases, including steatosis,
cirrhosis and hepatocellular carcinoma, and its infection is also associated with insulin …

Hepatitis C virus (HCV) is a small, enveloped RNA virus and a major cause of chronic liver
disease. Resolution of primary HCV infections depends upon the vigorous responses of …

Hepatitis C viral infection persists and becomes chronic in a majority of affected individuals.
Numerous factors have been described to explain how the virus manages to escape the …

Forkhead box (FOX) proteins play a crucial role in regulating the expression of genes
involved in multiple biological processes, such as metabolism, development, differentiation …

Adaptive T cell responses are critical for controlling HCV infection. While there is clinical
evidence of a relevant role for regulatory T cells in chronic HCV-infected patients, based on …

In contrast to traditional two-dimensional cell-culture conditions, three-dimensional (3D) cell-
culture models closely mimic complex in vivo conditions. However, constructing 3D cell …