Visceral leishmaniasis remains a public health problem worldwide. This illness was
included by the World Health Organization in the list of neglected tropical diseases targeted …

Leishmaniasis is a diverse group of clinical syndromes caused by protozoan parasites of the
genus Leishmania. The clinical manifestation of the disease varies from self-limiting …

Background Visceral leishmaniasis (VL or kala azar) is the most serious form of human
leishmaniasis, responsible for over 20,000 deaths annually, and post kala azar dermal …

Work in large part on Leishmania major in the 1980s identified two distinct apparently
counter-regulatory CD4+ T cell populations, T helper (h) 1 and Th2, that controlled …

Leishmaniasis is caused by protozoan Leishmania parasites that are transmitted through
female sandfly bites. The disease is predominantly endemic to the tropics and semi-tropics …

Leishmaniasis is a zoonotic and vector-borne infectious disease that is caused by the genus
Leishmania belonging to the trypanosomatid family. The protozoan parasite has a digenetic …

Experimental visceral leishmaniasis (VL) represents an exquisite model to study CD8+ T cell
responses in a context of chronic inflammation and antigen persistence, since it is …

Kupffer cells (KCs) represent the major phagocytic population within the liver and provide an
intracellular niche for the survival of a number of important human pathogens. Although KCs …

Leishmaniasis is a significant worldwide health problem for which no vaccine exists.
Activation of CD4+ and CD8+ T cells is crucial for the generation of protective immunity …

Human visceral leishmaniasis (HVL) is the most severe clinical form of a spectrum of
neglected tropical diseases caused by protozoan parasites of the genus Leishmania …