Simple mechanisms for the evolution of protein complexity
Proteins are tiny models of biological complexity: specific interactions among their many
amino acids cause proteins to fold into elaborate structures, assemble with other proteins …
amino acids cause proteins to fold into elaborate structures, assemble with other proteins …
Protein supramolecular structures: from self-assembly to nanovaccine design
Life-inspired protein supramolecular assemblies have recently attracted considerable
attention for the development of next-generation vaccines to fight against infectious …
attention for the development of next-generation vaccines to fight against infectious …
Interactions of the receptor binding domain of SARS-CoV-2 variants with hACE2: Insights from molecular docking analysis and molecular dynamic simulation
Simple Summary Since the onset of the COVID-19 pandemic in late 2019, SARS-CoV-2 has
evolved via genetic changes, resulting in numerous variants of concern (VOCs) and interest …
evolved via genetic changes, resulting in numerous variants of concern (VOCs) and interest …
Effect of structural stability of lipase in acetonitrile on its catalytic activity in EGCG esterification reaction: FTIR and MD simulation
S Wang, L Mo, B Wu, C Ma, H Wang - International Journal of Biological …, 2024 - Elsevier
Abstract In this study,(-)-Epigallocatechin-3-O-gallate (EGCG) esterification reaction was
catalyzed by Novozym 435, Lipozyme RM, Lipozyme TLIM, and lipase Amano 30SD in …
catalyzed by Novozym 435, Lipozyme RM, Lipozyme TLIM, and lipase Amano 30SD in …
In silico study of SARS‐CoV‐2 spike protein RBD and human ACE‐2 affinity dynamics across variants and Omicron subvariants
S Abeywardhana, M Premathilaka… - Journal of medical …, 2023 - Wiley Online Library
The coronavirus disease 2019 virus outbreak continues worldwide, with many variants
emerging, some of which are considered variants of concern (VOCs). The WHO designated …
emerging, some of which are considered variants of concern (VOCs). The WHO designated …
A computational comparative analysis of the binding mechanism of molnupiravir's active metabolite to RNA‐dependent RNA polymerase of wild‐type and Delta …
The antiviral drug molnupiravir targets the SARS‐CoV‐2 RNA‐dependent RNA polymerase
(RdRP) enzyme. Early treatment with molnupiravir reduced the risk of hospitalization or …
(RdRP) enzyme. Early treatment with molnupiravir reduced the risk of hospitalization or …
BODIPY-based fluorescent probes for sensing protein surface-hydrophobicity
Mapping surface hydrophobic interactions in proteins is key to understanding molecular
recognition, biological functions and is central to many protein misfolding diseases. Herein …
recognition, biological functions and is central to many protein misfolding diseases. Herein …
Computational prediction of the effect of mutations in the receptor-binding domain on the interaction between SARS-CoV-2 and human ACE2
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causing COVID-19
continues to mutate. Numerous studies have indicated that this viral mutation, particularly in …
continues to mutate. Numerous studies have indicated that this viral mutation, particularly in …
In silico screening of bioactive compounds of representative seaweeds to inhibit SARS-CoV-2 ACE2-bound omicron B. 1.1. 529 spike protein trimer
Omicron is an emerging SARS-CoV-2 variant, evolved from the Indian delta variant B. 1.617.
2, which is currently infecting worldwide. The spike glycoprotein, an important molecule in …
2, which is currently infecting worldwide. The spike glycoprotein, an important molecule in …
Comparative structural analysis of fruit and stem bromelain from Ananas comosus
Cysteine proteases in pineapple (Ananas comosus) plants are phytotherapeutical agents
that demonstrate anti-edematous, anti-inflammatory, anti-thrombotic and fibrinolytic …
that demonstrate anti-edematous, anti-inflammatory, anti-thrombotic and fibrinolytic …