Synergy by perturbing the gram-negative outer membrane: opening the door for gram-positive specific antibiotics

CMJ Wesseling, NI Martin - ACS Infectious Diseases, 2022 - ACS Publications
New approaches to target antibacterial agents toward Gram-negative bacteria are key, given
the rise of antibiotic resistance. Since the discovery of polymyxin B nonapeptide as a potent …

New potentiators of ineffective antibiotics: Targeting the Gram-negative outer membrane to overcome intrinsic resistance

K Klobucar, ED Brown - Current Opinion in Chemical Biology, 2022 - Elsevier
Because of the rise in antibiotic resistance and the dwindling pipeline of effective antibiotics,
it is imperative to explore avenues that breathe new life into existing drugs. This is …

Short peptides and their mimetics as potent antibacterial agents and antibiotic adjuvants

A Panjla, G Kaul, S Chopra, A Titz… - ACS Chemical …, 2021 - ACS Publications
Antimicrobial resistance (AMR) has been increasing unrelentingly worldwide, thus
negatively impacting human health. The discovery and development of novel antibiotics is …

Designing peptide amphiphiles as novel antibacterials and antibiotic adjuvants against gram-negative bacteria

H Xing, V Loya-Perez, J Franzen, PW Denton… - Bioorganic & Medicinal …, 2023 - Elsevier
Gram-negative strains are intrinsically resistant to most antibiotics due to the robust and
impermeable characteristic of their outer membrane. Self-assembling cationic peptide …

Supramolecular peptide assemblies as antimicrobial scaffolds

AW Simonson, MR Aronson, SH Medina - Molecules, 2020 - mdpi.com
Antimicrobial discovery in the age of antibiotic resistance has demanded the prioritization of
non-conventional therapies that act on new targets or employ novel mechanisms. Among …

Antimicrobial peptide zp37 inhibits Escherichia coli O157: H7 in alfalfa sprouts by inflicting damage in cell membrane and binding to DNA

L Yi, P Zeng, J Liu, KY Wong, EWC Chan, Y Lin… - Lwt, 2021 - Elsevier
Due to frequent outbreaks of sprouts-associated foodborne illness, sprouts have been
considered as a “high risk” food. In this study, the antimicrobial peptide zp37 (GIKAKIIIKIKK …

Amphipathic peptide antibiotics with potent activity against multidrug-resistant pathogens

J Shi, C Chen, D Wang, Z Tong, Z Wang, Y Liu - Pharmaceutics, 2021 - mdpi.com
The emergence and prevalence of multidrug-resistant (MDR) bacteria have posed a serious
threat to public health. Of particular concern are methicillin-resistant Staphylococcus aureus …

Membrane-disruptive engineered peptide amphiphiles restrain the proliferation of penicillins and cephalosporins resistant Vibrio alginolyticus and Vibrio …

P Zeng, Q Cheng, J Xu, Q Xu, Y Xu, W Gao, KY Wong… - Food Control, 2022 - Elsevier
Over 1 billion people rely on seafood as their primary source of protein and Vibrio spp. is the
most important pathogen of foodborne disease outbreak related to consumption of seafood …

[HTML][HTML] Investigation of antibiofilm activity, antibacterial activity, and mechanistic studies of an amphiphilic peptide against Acinetobacter baumannii

P Zeng, L Yi, J Xu, W Gao, C Xu, S Chen… - … et Biophysica Acta (BBA …, 2021 - Elsevier
Biofilm-producing pathogens, such as Acinetobacter baumannii, have aroused escalating
attention. Because these bacteria could secrete mixture with close-knit architecture and …

Graphene oxide-encapsulated baghdadite nanocomposite improved physical, mechanical, and biological properties of a vancomycin-loaded PMMA bone cement

M Tavakoli, A Najafinezhad, M Mirhaj… - Journal of …, 2024 - Taylor & Francis
Polymethyl methacrylate (PMMA) bone cement is commonly used in orthopedic surgeries to
fill the bone defects or fix the prostheses. These cements are usually containing amounts of …