Developing greener synthesis processes is an inescapable necessity to transform the
industrial landscape, mainly in the pharmaceutical sector, into a long-term, sustainable …

Solid-phase peptide synthesis (SPPS) is generally the method of choice for the chemical
synthesis of peptides, allowing routine synthesis of virtually any type of peptide sequence …

Peptides are gaining considerable attention as potential drugs. The so-called Fmoc/tBu solid-
phase synthesis is the method of choice for the synthesis of these molecules in both …

In conventional solid-phase peptide synthesis (SPPS), α-amino groups are protected with
alkoxycarbonyl groups (eg, 9-fluorenylmethoxycarbonyl [Fmoc]). However, during SPPS …

The deprotection step is crucial in order to secure a good quality product in Fmoc solid
phase peptide synthesis. 9-Fluorenylmethoxycarbonyl (Fmoc) removal is achieved by a two …

Designing programmable biomaterials that could act as extracellular matrices and permit
functionalization is a current need for tissue engineering advancement. DNA based …

Green binary solvent mixtures with a polarity and viscosity close to that of DMF perform
similarly in solid-phase peptide synthesis (SPPS). However, while coupling reactions readily …

By means of a systematic approach, several green solvent candidates were tested for their
feasibility to replace the reprotoxic dimethylformamide (DMF) as a solvent used in solid …

The chemical formation of the peptide bond has long fascinated and challenged organic
chemists. It requires not only the activation of the carboxyl group of an amino acid but also …

Phosphorylation is a major constituent of the CTD code, which describes the set of post-
translational modifications on 52 repeats of a YSPTSPS consensus heptad that orchestrates …