Machine intelligence in peptide therapeutics: A next‐generation tool for rapid disease screening

S Basith, B Manavalan, T Hwan Shin… - Medicinal research …, 2020 - Wiley Online Library
Discovery and development of biopeptides are time‐consuming, laborious, and dependent
on various factors. Data‐driven computational methods, especially machine learning (ML) …

Antimicrobial peptides derived from insects offer a novel therapeutic option to combat biofilm: A review

A Sahoo, SS Swain, A Behera, G Sahoo… - Frontiers in …, 2021 - frontiersin.org
Biofilms form a complex layer with defined structures, that attach on biotic or abiotic surfaces,
are tough to eradicate and tend to cause some resistance against most antibiotics. Several …

A bioinformatic study of antimicrobial peptides identified in the Black Soldier Fly (BSF) Hermetia illucens (Diptera: Stratiomyidae)

A Moretta, R Salvia, C Scieuzo, A Di Somma, H Vogel… - Scientific reports, 2020 - nature.com
Antimicrobial peptides (AMPs) play a key role in the innate immunity, the first line of defense
against bacteria, fungi, and viruses. AMPs are small molecules, ranging from 10 to 100 …

AntiCP 2.0: an updated model for predicting anticancer peptides

P Agrawal, D Bhagat, M Mahalwal… - Briefings in …, 2021 - academic.oup.com
Increasing use of therapeutic peptides for treating cancer has received considerable
attention of the scientific community in the recent years. The present study describes the in …

mAHTPred: a sequence-based meta-predictor for improving the prediction of anti-hypertensive peptides using effective feature representation

B Manavalan, S Basith, TH Shin, L Wei, G Lee - Bioinformatics, 2019 - academic.oup.com
Motivation Cardiovascular disease is the primary cause of death globally accounting for
approximately 17.7 million deaths per year. One of the stakes linked with cardiovascular …

iAFPs-EnC-GA: identifying antifungal peptides using sequential and evolutionary descriptors based multi-information fusion and ensemble learning approach

A Ahmad, S Akbar, M Tahir, M Hayat, F Ali - Chemometrics and Intelligent …, 2022 - Elsevier
Fungal infections have become a serious health concern for human beings worldwide.
Fungal infections usually occur when the invading fungus appear on a particular part of the …

iAtbP-Hyb-EnC: Prediction of antitubercular peptides via heterogeneous feature representation and genetic algorithm based ensemble learning model

S Akbar, A Ahmad, M Hayat, AU Rehman… - Computers in Biology …, 2021 - Elsevier
Tuberculosis (TB) is a worldwide illness caused by the bacteria Mycobacterium tuberculosis.
Owing to the high prevalence of multidrug-resistant tuberculosis, numerous traditional …

Machine learning prediction of antimicrobial peptides

G Wang, II Vaisman, ML van Hoek - Computational peptide science …, 2022 - Springer
Antibiotic resistance constitutes a global threat and could lead to a future pandemic. One
strategy is to develop a new generation of antimicrobials. Naturally occurring antimicrobial …

iBCE-EL: a new ensemble learning framework for improved linear B-cell epitope prediction

B Manavalan, RG Govindaraj, TH Shin… - Frontiers in …, 2018 - frontiersin.org
Identification of B-cell epitopes (BCEs) is a fundamental step for epitope-based vaccine
development, antibody production, and disease prevention and diagnosis. Due to the …

Computer-aided prediction and design of IL-6 inducing peptides: IL-6 plays a crucial role in COVID-19

A Dhall, S Patiyal, N Sharma, SS Usmani… - Briefings in …, 2021 - academic.oup.com
Abstract Interleukin 6 (IL-6) is a pro-inflammatory cytokine that stimulates acute phase
responses, hematopoiesis and specific immune reactions. Recently, it was found that the IL …