The intricacy of diseases, shaped by intrinsic processes like immune system exhaustion and
hyperactivation, highlights the potential of immune renormalization as a promising strategy …

Owing to its memory and plasticity, the immune system (IS) is capable of recording all the
immunological experiences and stimuli it was exposed to. The combination of type, dose …

Human Vγ2Vδ2 T cells play important roles in mediating immunity against microbial
pathogens and have potent anti‐tumor activity. Vγ2Vδ2 T cells recognize the …

Unconventional T cells include γδ T cells, invariant Natural Killer T cells (iNKT) cells and
Mucosal Associated Invariant T (MAIT) cells, which are distinguished from conventional T …

Immunosenescence is defined as the state of dysregulated immune function that contributes
to the increased susceptibility to infection, cancer and autoimmune diseases observed in old …

The immune system of semi-(from≥ 105 to< 110 years old) and supercentenarians (≥ 110
years old), ie oldest centenarians, is thought to have characteristics that allow them to reach …

Compromised immunity contributes to the decreased ability of the elderly to control
infectious disease and to their generally poor response to vaccination. It is controversial as …

Alzheimer's disease (AD) is the most common form of dementia affecting millions of people
worldwide. While different immunotherapies are imminent, currently only disease-modifying …

Decreases in immune responsiveness with age are thought to contribute to the increased
incidence and severity of infectious disease among the elderly. Several interventions …

The emergence of viruses with pandemic potential such as the SARS-CoV-2 coronavirus
causing COVID-19 poses a global health challenge. There is remarkable progress in …