Metabolic dysfunction-associated steatotic liver disease (MASLD) encompasses a wide
spectrum of liver injuries, ranging from hepatic steatosis, metabolic dysfunction-associated …

Therapeutic approaches to reduce atherogenic lipid and lipoprotein levels remain the most
effective and assessable strategies to prevent and treat cardiovascular disease. The …

Aim To investigate the potential causal relationship between non‐alcoholic fatty liver
disease (NAFLD) and complications in type 1 diabetes (T1D) and type 2 diabetes (T2D) …

Abstract Objectives The Glucokinase Regulatory Protein GKRP, encoded by GCKR, enables
acute regulation of liver glucokinase to support metabolic demand. The common human …

Backgrounds/Aims Transmembrane 6 superfamily member 2 (TM6SF2) E167K variant is
closely associated with the occurrence and development of metabolic dysfunction …

Multiple genome-wide association studies (GWAS) have identified specific genetic variants
in the coiled-coil domain containing 92 (CCDC92) locus that is associated with obesity and …

This work was supported by NIH grants DK099257 to AS-G and DN, TR003289, DK096990,
DK117881, DK119973, TR002383 to AS-G and DK135606 to AS-G and MTM This work was …

Genetic variants in transmembrane 6 superfamily member 2 (TM6SF2), such as E167K, are
associated with atherosclerotic cardiovascular disease (ASCVD). Chronic inflammation and …

The identification of genetic variants that are highly associated with human disease
presentation should be followed by the validation and investigation into the pathways that …

Excessive fat deposition affects the efficiency and quality of broiler meat production. To
understand the molecular mechanism underlying abdominal fat content of broiler lines …