Adeno-associated virus (AAV) has emerged as a leading platform for gene delivery for
treating various diseases due to its excellent safety profile and efficient transduction to …

Protein instability caused by exposure to external additives or severe stress may result in
different diseases. Of these diseases, many are triggered by protein misfolding and …

Abstract In 1989, Manning, Patel, and Borchardt wrote a review of protein stability (Manning
et al., Pharm. Res. 6: 903–918, 1989), which has been widely referenced ever since. At the …

The broadest clinical application of siRNA therapeutics will be facilitated by drug-loaded
delivery systems that maintain stability and potency for long times under ambient conditions …

Abstract Development of formulations for protein drugs requiring high dosing (in the order of
mg/kg) may become challenging for solubility limited proteins and for the subcutaneous (SC) …

ABSTRACT Polysorbates 20 and 80 (Tween® 20 and Tween® 80) are used in the
formulation of biotherapeutic products for both preventing surface adsorption and as …

In recent decades, protein-based therapeutics have substantially expanded the field of
molecular pharmacology due to their outstanding potential for the treatment of disease …

Proteins as amphiphilic, surface-active macromolecules, demonstrate substantial interfacial
activity, which causes considerable impact on their multifarious applications. A commonly …

Solid-state is the preferred choice for storage of protein therapeutics to improve stability and
preserve the biological activity by decreasing the physical and chemical degradation …

Understanding protein self-assembly is important for many biological and industrial
processes. Proteins can self-assemble into crystals, filaments, gels, and other amorphous …