Simple Summary The immune system provides surveillance measures to identify and
remove damaged cell types at an early stage. One important example involves the NKG2D …

Background Melanoma is typically regarded as the most dangerous form of skin cancer.
Although surgical removal of in situ lesions can be used to effectively treat metastatic …

Tumor is one of the biggest threats to human health. Though tumor therapy has been
dramatically advanced by the progress of technology and research in recent decades, it is …

Precise discrimination and eradication of cancer cells by immune cells independent of
antigen recognition is promising for solid tumor therapeutics, yet remains a tremendous …

Anti-CD38 monoclonal antibodies like Daratumumab (Dara) are effective in multiple
myeloma (MM); however, drug resistance ultimately occurs and the mechanisms behind this …

The genesis and progression of tumors are multifaceted processes influenced by genetic
mutations within the tumor cells and the dynamic interplay with their surrounding milieu …

Background Glioblastoma multiforme (GBM) is a highly aggressive brain tumor with a poor
prognosis. Current treatment options are limited and often ineffective. CAR T cell therapy …

Background With the gradual understanding of glioma development and the immune
microenvironment, many immune cells have been discovered. Despite the growing …

CRISPR screen technology enables systematic and scalable interrogation of gene function
by using the CRISPR-Cas9 system to perturb gene expression. In the field of cancer …

Natural killer (NK) cell immunotherapy has gained attention as a promising strategy for
treatment of various malignancies. In this study, we used a genome-wide CRISPR screen to …