CHARMM at 45: Enhancements in accessibility, functionality, and speed
Since its inception nearly a half century ago, CHARMM has been playing a central role in
computational biochemistry and biophysics. Commensurate with the developments in …
computational biochemistry and biophysics. Commensurate with the developments in …
Quantitative approaches for decoding the specificity of the human T cell repertoire
ZS Ghoreyshi, JT George - Frontiers in Immunology, 2023 - frontiersin.org
T cell receptor (TCR)-peptide-major histocompatibility complex (pMHC) interactions play a
vital role in initiating immune responses against pathogens, and the specificity of TCRpMHC …
vital role in initiating immune responses against pathogens, and the specificity of TCRpMHC …
Tuning T cell receptor sensitivity through catch bond engineering
Adoptive cell therapy using engineered T cell receptors (TCRs) is a promising approach for
targeting cancer antigens, but tumor-reactive TCRs are often weakly responsive to their …
targeting cancer antigens, but tumor-reactive TCRs are often weakly responsive to their …
Mechanical force matters in early T cell activation
M Fritzsche, K Kruse - Proceedings of the National Academy of Sciences, 2024 - pnas.org
Mechanical force has repeatedly been highlighted to be involved in T cell activation.
However, the biological significance of mechanical force for T cell receptor signaling …
However, the biological significance of mechanical force for T cell receptor signaling …
Mechanobiology of T cell activation: to catch a bond
T cell activation is a critical event in the adaptive immune response, indispensable for cell-
mediated and humoral immunity as well as for immune regulation. Recent years have …
mediated and humoral immunity as well as for immune regulation. Recent years have …
Force-induced site-specific enzymatic cleavage probes reveal that serial mechanical engagement boosts T cell activation
The T cell membrane is studded with> 104 T cell receptors (TCRs) that are used to scan
target cells to identify short peptide fragments associated with viral infection or cancerous …
target cells to identify short peptide fragments associated with viral infection or cancerous …
Harnessing αβ T cell receptor mechanobiology to achieve the promise of immuno-oncology
EL Reinherz, W Hwang… - Proceedings of the …, 2023 - National Acad Sciences
T cell receptors (TCR) on cytolytic T lymphocytes (CTLs) recognize" foreign" antigens bound
in the groove of major histocompatibility complex (MHC) molecules (H-2 in mouse and HLA …
in the groove of major histocompatibility complex (MHC) molecules (H-2 in mouse and HLA …
Catch bond models may explain how force amplifies TCR signaling and antigen discrimination
The TCR integrates forces in its triggering process upon interaction with pMHC. Force elicits
TCR catch-slip bonds with strong pMHCs but slip-only bonds with weak pMHCs. We …
TCR catch-slip bonds with strong pMHCs but slip-only bonds with weak pMHCs. We …
Mechanotransduction as a major driver of cell behaviour: Mechanisms, and relevance to cell organization and future research
PH Puech, P Bongrand - Open Biology, 2021 - royalsocietypublishing.org
How do cells process environmental cues to make decisions? This simple question is still
generating much experimental and theoretical work, at the border of physics, chemistry and …
generating much experimental and theoretical work, at the border of physics, chemistry and …
Dynamic allostery in the peptide/MHC complex enables TCR neoantigen selectivity
The inherent antigen cross-reactivity of the T cell receptor (TCR) is balanced by high
specificity. Surprisingly, TCR specificity often manifests in ways not easily interpreted from …
specificity. Surprisingly, TCR specificity often manifests in ways not easily interpreted from …