Immunity to SARS‐CoV‐2 induced by infection or vaccination
Adaptive immune responses play critical roles in viral clearance and protection against re‐
infection, and SARS‐CoV‐2 is no exception. What is exceptional is the rapid …
infection, and SARS‐CoV‐2 is no exception. What is exceptional is the rapid …
Computational network biology: data, models, and applications
Biological entities are involved in intricate and complex interactions, in which uncovering the
biological information from the network concepts are of great significance. Benefiting from …
biological information from the network concepts are of great significance. Benefiting from …
Reversal of cancer gene expression correlates with drug efficacy and reveals therapeutic targets
The decreasing cost of genomic technologies has enabled the molecular characterization of
large-scale clinical disease samples and of molecular changes upon drug treatment in …
large-scale clinical disease samples and of molecular changes upon drug treatment in …
Computational models for predicting drug responses in cancer research
F Azuaje - Briefings in bioinformatics, 2017 - academic.oup.com
The computational prediction of drug responses based on the analysis of multiple types of
genome-wide molecular data is vital for accomplishing the promise of precision medicine in …
genome-wide molecular data is vital for accomplishing the promise of precision medicine in …
[HTML][HTML] The roles of inflammation and immune mechanisms in Alzheimer's disease
LJ Van Eldik, MC Carrillo, PE Cole, D Feuerbach… - Alzheimer's & Dementia …, 2016 - Elsevier
Abstract The Alzheimer's Association's Research roundtable met in April 2015 to explore the
role of neuroinflammatory mechanisms in the progression of Alzheimer's disease (AD). The …
role of neuroinflammatory mechanisms in the progression of Alzheimer's disease (AD). The …
Nanocarrier design–function relationship: the prodigious role of properties in regulating biocompatibility for drug delivery applications
The concept of drug delivery systems as a magic bullet for the delivery of bioactive
compounds has emerged as a promising approach in the treatment of different diseases …
compounds has emerged as a promising approach in the treatment of different diseases …
Lessons learned from two decades of anticancer drugs
Tremendous efforts have been made to elucidate the basis of cancer biology with the aim of
promoting anticancer drug development. Especially over the past 20 years, anticancer drug …
promoting anticancer drug development. Especially over the past 20 years, anticancer drug …
Recent advances in small molecule based cancer immunotherapy
B Cheng, WE Yuan, J Su, Y Liu, J Chen - European Journal of Medicinal …, 2018 - Elsevier
Immunotherapy has been increasingly utilized for the treatment of cancer. Currently
available cancer immunotherapies mainly involve the use of antibodies, which have …
available cancer immunotherapies mainly involve the use of antibodies, which have …
COIMMR: a computational framework to reveal the contribution of herbal ingredients against human cancer via immune microenvironment and metabolic …
S Tian, Y Li, J Xu, L Zhang, J Zhang, J Lu… - Briefings in …, 2023 - academic.oup.com
Immune evasion and metabolism reprogramming have been regarded as two vital hallmarks
of the mechanism of carcinogenesis. Thus, targeting the immune microenvironment and the …
of the mechanism of carcinogenesis. Thus, targeting the immune microenvironment and the …
Multi-compartment 3D-cultured organ-on-a-chip: towards a biomimetic lymph node for drug development
The interaction of immune cells with drugs and/or with other cell types should be
mechanistically investigated in order to reduce attrition of new drug development. However …
mechanistically investigated in order to reduce attrition of new drug development. However …