Multivalent glycocyclopeptides: conjugation methods and biological applications

D Goyard, AMS Ortiz, D Boturyn… - Chemical Society …, 2022 - pubs.rsc.org
Click chemistry was extensively used to decorate synthetic multivalent scaffolds with glycans
to mimic the cell surface glycocalyx and to develop applications in glycosciences …

Building synergistic nanoplatforms via dendrimer-small organic molecule handshakes: Heterocycle ligation as a promising strategy

CR Nair, KG Sreejalekshmi - Materials Today Chemistry, 2024 - Elsevier
Branching out in a cascade fashion from a central core and presenting multivalent
cooperativity, dendrimers, with their well-defined architecture, received significant attention …

Offsetting Low-Affinity Carbohydrate Binding with Covalency to Engage Sugar-Specific Proteins for Tumor-Immune Proximity Induction

BPM Lake, AF Rullo - ACS Central Science, 2023 - ACS Publications
Carbohydrate-binding receptors are often used by the innate immune system to potentiate
inflammation, target endocytosis/destruction, and adaptive immunity (eg, CD206, DC-SIGN …

Synthesis and anticancer properties of dendritic glycoconjugates containing multiple o-carborane clusters

BR Swain, SR Jena, SK Beriha, CS Mahanta… - New Journal of …, 2023 - pubs.rsc.org
Boron-rich glycodendrimers containing three to six peripheral hydrophilic glucose moieties
and three ortho-carborane clusters have been synthesized. Adding more number of glucose …

Reconstituting the immune killing functions and improving the pharmacokinetics of nanobodies by rhamnolipid conjugation

Y Li, D Li, H Lin, D Wang, J Zhao, Z Wang… - Journal of Controlled …, 2025 - Elsevier
Nanobodies (Nbs) hold great promise as next-generation cancer immunotherapies, but their
efficacy is hindered by their poor pharmacokinetics and the inability to trigger Fc-mediated …

Practical Antibody Recruiting by Metabolic Labeling with Caged Glycans

H Milawati, Y Manabe, T Matsumoto… - Angewandte Chemie …, 2023 - Wiley Online Library
We propose a de novo glycan display approach that combines metabolic labeling and a
glycan‐caging strategy as a facile editing method for cell‐surface glycans. This method …