Single-molecule localization microscopy
Single-molecule localization microscopy (SMLM) describes a family of powerful imaging
techniques that dramatically improve spatial resolution over standard, diffraction-limited …
techniques that dramatically improve spatial resolution over standard, diffraction-limited …
Regulatory mechanisms in T cell receptor signalling
The remarkable T cell receptor (TCR) performs essential functions in the initiation of
intracellular signals required for T cell development, repertoire selection and effector …
intracellular signals required for T cell development, repertoire selection and effector …
PD-1 blockade in subprimed CD8 cells induces dysfunctional PD-1+CD38hi cells and anti-PD-1 resistance
V Verma, RK Shrimali, S Ahmad, W Dai, H Wang… - Nature …, 2019 - nature.com
Understanding resistance to antibody to programmed cell death protein 1 (PD-1; anti-PD-1)
is crucial for the development of reversal strategies. In anti-PD-1-resistant models …
is crucial for the development of reversal strategies. In anti-PD-1-resistant models …
Function of novel anti-CD19 chimeric antigen receptors with human variable regions is affected by hinge and transmembrane domains
L Alabanza, M Pegues, C Geldres, V Shi, JJW Wiltzius… - Molecular Therapy, 2017 - cell.com
Anti-CD19 chimeric antigen receptor (CAR) T cells have caused remissions of B cell
malignancies, but problems including cytokine-mediated toxicity and short persistence of …
malignancies, but problems including cytokine-mediated toxicity and short persistence of …
DNA origami–based artificial antigen-presenting cells for adoptive T cell therapy
Nanosized artificial antigen-presenting cells (aAPCs) with efficient signal presentation hold
great promise for in vivo adoptive cell therapy. Here, we used DNA origami nanostructures …
great promise for in vivo adoptive cell therapy. Here, we used DNA origami nanostructures …
Plant lipids: Key players of plasma membrane organization and function
AM Cassim, P Gouguet, J Gronnier, N Laurent… - Progress in Lipid …, 2019 - Elsevier
The plasma membrane (PM) is the biological membrane that separates the interior of all
cells from the outside. The PM is constituted of a huge diversity of proteins and lipids. In this …
cells from the outside. The PM is constituted of a huge diversity of proteins and lipids. In this …
The interplay between membrane topology and mechanical forces in regulating T cell receptor activity
T cells are critically important for host defense against infections. T cell activation is specific
because signal initiation requires T cell receptor (TCR) recognition of foreign antigen …
because signal initiation requires T cell receptor (TCR) recognition of foreign antigen …
Mechanosensing through immunoreceptors
The immune response is orchestrated by a variety of immune cells. The function of each cell
is determined by the collective signals from various immunoreceptors, whose expression …
is determined by the collective signals from various immunoreceptors, whose expression …
Canonical T cell receptor docking on peptide–MHC is essential for T cell signaling
INTRODUCTION T cell receptor (TCR) recognition of peptide–major histocompatibility
complexes (pMHCs) is one of the most diverse receptor–ligand interactions in biology …
complexes (pMHCs) is one of the most diverse receptor–ligand interactions in biology …
Integrin nanoclusters can bridge thin matrix fibres to form cell–matrix adhesions
Integrin-mediated cell–matrix adhesions are key to sensing the geometry and rigidity of
extracellular environments and influence vital cellular processes. In vivo, the extracellular …
extracellular environments and influence vital cellular processes. In vivo, the extracellular …