Prediction of the ideal-gas thermodynamic properties for water

CW Wang, J Wang, YS Liu, J Li, XL Peng, CS Jia… - Journal of Molecular …, 2021 - Elsevier
We report a suitable analytical representation of the ideal-gas Gibbs free energy for water,
and also derive an efficient analytical representation of the ideal-gas entropy from the former …

[HTML][HTML] Redesigned chondroitinase ABC degrades inhibitory chondroitin sulfate proteoglycans in vitro and in vivo in the stroke-injured rat brain

NL Khait, S Zuccaro, D Abdo, H Cui, R Siu, E Ho… - Biomaterials, 2025 - Elsevier
Injuries to the central nervous system, such as stroke and traumatic spinal cord injury, result
in an aggregate scar that both limits tissue degeneration and inhibits tissue regeneration …

Reengineering biocatalysts: Computational redesign of chondroitinase ABC improves efficacy and stability

MH Hettiaratchi, MJ O'Meara, TR O'Meara… - Science …, 2020 - science.org
Maintaining biocatalyst stability and activity is a critical challenge. Chondroitinase ABC
(ChABC) has shown promise in central nervous system (CNS) regeneration, yet its …

Comparing similar versions of a connecting helix on the structure of Chondroitinase ABC I

M Pourahmadi, A Shirdel, N Jamshidi, V Jafarian… - Enzyme and Microbial …, 2022 - Elsevier
Regarding the existence of similar helices on the structure of different proteins, recently,
novel variants of Chondroitinase ABC I (cABC I) have been constructed, where a …

Enzyme Kinetics Features of the Representative Engineered Recombinants of Chondroitinase ABC I

K Moradi, Z Bayani, V Jafarian, A Shirdel - The Protein Journal, 2023 - Springer
Abstract Chondroitinase ABC I (cABC I) from Proteus vulgaris is an important enzyme in
medicinal biotechnology due to its ability to help axon regeneration after spinal cord injury …

Bioinformatics and experimental studies on the structural roles of a surface-exposed α-helix at the C-terminal domain of Chondroitinase ABC I

N Jamshidi, A Shirdel, M Pourahmadi, V Jafarian… - International Journal of …, 2020 - Elsevier
A series of single and double mutants generated on residues of a surfaced-exposed helix at
the C-terminal domain of chondroitinase ABC I (cABC I) from proteus vulgaris. M886A …

Towards an Injectable Hydrogel for the Delivery of Thermostable Chondroitinase ABC

SM Zuccaro - 2022 - search.proquest.com
Chondroitinase-ABC (ChABC) is a bacterial enzyme that has immense potential as a
therapy for central nervous system injuries due to its ability to degrade the chondroitin …

Chondroitinase abc mutants and methods of manufacture and use thereof

MS Shoichet, MH Hettiaratchi, TR O'meara… - US Patent App. 17 …, 2023 - Google Patents
2023-09-13 Assigned to THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
reassignment THE REGENTS OF THE UNIVERSITY OF CALIFORNIA ASSIGNMENT OF …