Biology and significance of alpha‐fetoprotein in hepatocellular carcinoma

PR Galle, F Foerster, M Kudo, SL Chan… - Liver …, 2019 - Wiley Online Library
Hepatocellular carcinoma (HCC) is one of the most common causes of cancer‐related
deaths globally due, in part, to the majority of patients being diagnosed with intermediate or …

Risk factors and prevention of hepatocellular carcinoma in the era of precision medicine

N Fujiwara, SL Friedman, N Goossens, Y Hoshida - Journal of hepatology, 2018 - Elsevier
Patients who develop chronic fibrotic liver disease, caused by viral or metabolic aetiologies,
are at a high risk of developing hepatocellular carcinoma (HCC). Even after complete HCC …

Deep learning–based multi-omics integration robustly predicts survival in liver cancer

K Chaudhary, OB Poirion, L Lu, LX Garmire - Clinical Cancer Research, 2018 - AACR
Identifying robust survival subgroups of hepatocellular carcinoma (HCC) will significantly
improve patient care. Currently, endeavor of integrating multi-omics data to explicitly predict …

[HTML][HTML] The landscape of alpha fetoprotein in hepatocellular carcinoma: where are we?

X Hu, R Chen, Q Wei, X Xu - International journal of biological …, 2022 - ncbi.nlm.nih.gov
Hepatocellular carcinoma (HCC) is the most common primary liver cancer and has been
acknowledged as a leading cause of death among cirrhosis patients. Difficulties in early …

Inhibition of acetyl-CoA carboxylase by phosphorylation or the inhibitor ND-654 suppresses lipogenesis and hepatocellular carcinoma

JSV Lally, S Ghoshal, DK DePeralta, O Moaven, L Wei… - Cell metabolism, 2019 - cell.com
The incidence of hepatocellular carcinoma (HCC) is rapidly increasing due to the
prevalence of obesity and non-alcoholic fatty liver disease, but the molecular triggers that …

Epigenetic associations between lncRNA/circRNA and miRNA in hepatocellular carcinoma

TS Han, K Hur, HS Cho, HS Ban - Cancers, 2020 - mdpi.com
Simple Summary Non-coding RNAs such as microRNAs, long non-coding RNAs, and
circular RNAs contribute to the development and progression of hepatocellular carcinoma …

Precision treatment in advanced hepatocellular carcinoma

X Yang, C Yang, S Zhang, H Geng, AX Zhu… - Cancer Cell, 2024 - cell.com
The past decade has witnessed significant advances in the systemic treatment of advanced
hepatocellular carcinoma (HCC). Nevertheless, the newly developed treatment strategies …

MRI radiomics features predict immuno-oncological characteristics of hepatocellular carcinoma

SJ Hectors, S Lewis, C Besa, MJ King, D Said… - European …, 2020 - Springer
Objective To assess the value of qualitative and quantitative MRI radiomics features for
noninvasive prediction of immuno-oncologic characteristics and outcomes of hepatocellular …

Molecular liver cancer prevention in cirrhosis by organ transcriptome analysis and lysophosphatidic acid pathway inhibition

S Nakagawa, L Wei, WM Song, T Higashi, S Ghoshal… - Cancer cell, 2016 - cell.com
Cirrhosis is a milieu that develops hepatocellular carcinoma (HCC), the second most lethal
cancer worldwide. HCC prediction and prevention in cirrhosis are key unmet medical needs …

Integrated analysis of immunity-and ferroptosis-related biomarker signatures to improve the prognosis prediction of hepatocellular carcinoma

X Du, Y Zhang - Frontiers in genetics, 2020 - frontiersin.org
Background Hepatocellular carcinoma (HCC) is a common malignant tumor with high
mortality and poor prognoses around the world. Ferroptosis is a new form of cell death, and …