Adipokines in non-alcoholic fatty liver disease: are we on the road toward new biomarkers and therapeutic targets?

V Francisco, MJ Sanz, JT Real, P Marques… - Biology, 2022 - mdpi.com
Simple Summary Non-alcoholic fatty liver disease (NAFLD) is an unmet medical need due to
its increasingly high incidence, severe clinical consequences, and the absence of feasible …

Asprosin, a novel pleiotropic adipokine implicated in fasting and obesity-related cardio-metabolic disease: Comprehensive review of preclinical and clinical evidence

K Shabir, JE Brown, I Afzal, S Gharanei… - Cytokine & Growth …, 2021 - Elsevier
White adipose tissue is a dynamic endocrine organ that releases an array of adipokines,
which play a key role in regulating metabolic homeostasis and multiple other physiological …

[HTML][HTML] Di-(2-ethylhexyl) phthalate substitutes accelerate human adipogenesis through PPARγ activation and cause oxidative stress and impaired metabolic …

A Schaffert, I Karkossa, E Ueberham… - Environment …, 2022 - Elsevier
The obesity pandemic is presumed to be accelerated by endocrine disruptors such as
phthalate-plasticizers, which interfere with adipose tissue function. With the restriction of the …

The parallel reaction monitoring-parallel accumulation–serial fragmentation (prm-PASEF) approach for multiplexed absolute quantitation of proteins in human plasma

A Brzhozovskiy, A Kononikhin, AE Bugrova… - Analytical …, 2022 - ACS Publications
Mass spectrometry (MS)-based quantitative proteomic methods have become some of the
major tools for protein biomarker discovery and validation. The recently developed parallel …

20 Years with SGBS cells-a versatile in vitro model of human adipocyte biology

D Tews, RE Brenner, R Siebert, KM Debatin… - International Journal of …, 2022 - nature.com
Abstract 20 years ago, we described a human cell strain derived from subcutaneous
adipose tissue of an infant supposed to have Simpson-Golabi-Behmel Syndrome (SGBS) …

Low circulating levels of neuregulin 4 as a potential biomarker associated with the severity and prognosis of obesity-related metabolic diseases: a systematic review

K Ziqubu, PV Dludla, SXH Mthembu, B Nkambule… - Adipocyte, 2024 - Taylor & Francis
ABSTRACT Background Neuregulin 4 (Nrg4) is a brown adipose tissue-derived adipokine
that greatly affects systemic metabolism and improves metabolic derangements. Although …

Multiomics reveal unique signatures of human epiploic adipose tissue related to systemic insulin resistance

L Krieg, K Didt, I Karkossa, SH Bernhart, S Kehr… - Gut, 2022 - gut.bmj.com
Objective Human white adipose tissue (AT) is a metabolically active organ with distinct
depot-specific functions. Despite their locations close to the gastrointestinal tract, mesenteric …

Systematic review of multi-omics approaches to investigate toxicological effects in macrophages

I Karkossa, S Raps, M von Bergen… - International Journal of …, 2020 - mdpi.com
Insights into the modes of action (MoAs) of xenobiotics are of utmost importance for the
definition of adverse outcome pathways (AOPs), which are essential for a mechanism-based …

Second Special Issue on Methods for Omics Research: Proteome Research and Beyond

L Florens, MQ Dong, J LaBaer - Journal of Proteome Research, 2023 - ACS Publications
This Second Special Issue compiles 19 studies answering our open call to describe novel,
or at least significantly updated, Methods for Omics Research. The common thread among …

A multiplex protein panel assay determines disease severity and is prognostic about outcome in COVID-19 patients

Z Wang, A Cryar, O Lemke, D Ludwig, P Tober-Lau… - medRxiv, 2021 - medrxiv.org
Global healthcare systems continue to be challenged by the COVID-19 pandemic, and there
is a need for clinical assays that can both help to optimize resource allocation and …