A systematic review of venetoclax for the treatment of unfit AML patients in real-world: is all that glitters gold?

A Solana-Altabella, R Rodríguez-Veiga… - Annals of …, 2024 - Springer
Acute myeloid leukemia (AML) is an aggressive hematological disease that mainly affects
elderly patients. Following the randomized VIALE-A trial, current standard treatment in …

Treatment of acute myeloid leukemia in older adults

A Alsouqi, E Geramita, A Im - Cancers, 2023 - mdpi.com
Simple Summary In this review article, we describe the landscape of available treatments for
older and medically unfit patients with AML. We review the historical practice of AML …

[PDF][PDF] 维奈克拉联合方案一线治疗新诊断急性髓系白血病的单中心真实世界研究

吴迪, 陈智超, 黎纬明 - 临床血液学杂志, 2024 - lcxy.whuhzzs.com
目的: 靶向药物BCL-2 抑制剂维奈克拉(venetoclax, VEN) 的出现革新了急性髓系白血病(acute
myeloidleukemia, AML) 的治疗格局, 尤其是对于老年或不适合强化疗的患者 …

Validation of SIE/SIES/GITMO consensus criteria for unfitness to predict early mortality and survival in acute myeloid leukaemia patients treated with hypomethylating …

V Apolito, G Arrigo, L Vasseur, M Olivi… - British Journal of …, 2023 - search.ebscohost.com
This article discusses the validation of the SIE/SIES/GITMO consensus criteria, also known
as the Ferrara criteria, for predicting early mortality and survival in acute myeloid leukemia …

Molecular ontogeny underlies the benefit of adding venetoclax to hypomethylating agents in newly diagnosed AML patients

S Shimony, JS Garcia, J Keating, EC Chen, MR Luskin… - Leukemia, 2024 - nature.com
The clinical impact of molecular ontogeny in acute myeloid leukemia (AML) was defined in
patients treated with intensive chemotherapy. In a cohort of 314 newly diagnosed AML …

[HTML][HTML] Safety and infection risk factors in elderly acute myeloid leukemia patients undergoing induction therapy with venetoclax combined with hypomethylating …

W Zhu, L Zhu, X Hu, E Chen, L Xue… - American Journal of …, 2024 - pmc.ncbi.nlm.nih.gov
Objective: To retrospectively analyze the incidence of infections in elderly acute myeloid
leukemia (AML) patients undergoing induction therapy with venetoclax combined with …

Clinical Pharmacology and Side Effects of Venetoclax in Hematologic Malignancies

Y Yan, Y Guo, Z Wang, W He, Y Zhu… - Current Drug …, 2024 - benthamdirect.com
Venetoclax is a first-in-class B-cell lymphoma/lymphoma-2 (BCL-2) inhibitor that induces
apoptosis in malignant cells through the inhibition of BCL-2. The clinical response to …

Adapting the Fitness Criteria for Non-Intensive Treatments in Older Patients with Acute Myeloid Leukemia to the Use of Venetoclax-Hypomethylating Agents …

G Rossi, E Borlenghi, P Zappasodi, F Lussana… - Cancers, 2024 - mdpi.com
Simple Summary In older AML patients, their clinical fitness is of utmost importance for
choosing the most appropriate therapy. Therefore, treatment-specific fitness criteria were …

Rethinking the definition of 'less intensive'for venetoclax‐combining regimens in acute myeloid leukaemia patients

E Borlenghi, AM Roccaro… - British Journal of …, 2023 - Wiley Online Library
Invasive fungal infections (IFIs), mainly due to pulmonary aspergillosis, are considered a
serious complication in acute leukaemia, with an unfavourable impact on patient. In this well …

Time to define and refine maintenance strategies in acute myeloid leukaemia

CC Chua, A Gómez-De León - The Lancet. Haematology, 2024 - pubmed.ncbi.nlm.nih.gov
Time to define and refine maintenance strategies in acute myeloid leukaemia Time to define
and refine maintenance strategies in acute myeloid leukaemia Lancet Haematol. 2024 Apr;11(4):e246-e247 …