Therapeutic potential of omega-3 fatty acid-derived epoxyeicosanoids in cardiovascular and inflammatory diseases

WH Schunck, A Konkel, R Fischer… - Pharmacology & …, 2018 - Elsevier
Numerous benefits have been attributed to dietary long-chain omega-3 polyunsaturated fatty
acids (n-3 LC-PUFAs), including protection against cardiac arrhythmia, triglyceride-lowering …

Oxygenation of polyunsaturated fatty acids by cytochrome P450 monooxygenates

EH Oliw - Progress in lipid research, 1994 - Elsevier
1. Arachidonic acid 2. Other unsaturated fatty acids B. Hydroxylations 1. Hydroxylation of the
to-side chain of arachidonic acid 2. Hydroxylation of the to-side chain of other unsaturated …

Methods of reducing the risk of a cardiovascular event in a subject on statin therapy

P Soni - US Patent 9,610,272, 2017 - Google Patents
In various embodiments, the present invention provides methods of reducing the risk of a
cardiovascular event in a subject on statin therapy and, in particular, a method of reducing …

Stable pharmaceutical composition and methods of using same

M Manku - US Patent 8,298,554, 2012 - Google Patents
US8298554B2 - Stable pharmaceutical composition and methods of using same - Google
Patents US8298554B2 - Stable pharmaceutical composition and methods of using same …

Compositions comprising EPA and obeticholic acid and methods of use thereof

JS Zakrzewski - US Patent 9,814,733, 2017 - Google Patents
US9814733B2 - Compositions comprising EPA and obeticholic acid and methods of use
thereof - Google Patents US9814733B2 - Compositions comprising EPA and obeticholic …

Compositions and methods for lowering triglycerides without raising LDL-C levels in a subject on concomitant statin therapy

I Osterloh, P Wicker, R Braeckman, P Soni… - US Patent …, 2013 - Google Patents
US8455472B2 - Compositions and methods for lowering triglycerides without raising LDL-C
levels in a subject on concomitant statin therapy - Google Patents US8455472B2 …

EET homologs potently dilate coronary microvessels and activate BKCa channels

Y Zhang, CL Oltman, T Lu, HC Lee… - American Journal …, 2001 - journals.physiology.org
Epoxyeicosatrienoic acids (EETs) are released from endothelial cells and potently dilate
small arteries by hyperpolarizing vascular myocytes. In the present study, we investigated …

Methods of treating hypertriglyceridemia

M Manku, I Osterloh, P Wicker, R Braeckman… - US Patent …, 2012 - Google Patents
In various embodiments, the present invention provides methods of treating and/or
preventing cardiovascular-related disease and, in particular, a method of blood lipid therapy …

Pharmaceutical compositions comprising epa and a cardiovascular agent and methods of using the same

M Manku, I Osterloh, P Wicker, R Braeckman… - US Patent …, 2021 - Google Patents
The present invention relates to, inter alia, pharmaceutical compositions comprising EPA
and one or more cardiovascular agents, and to therapeutic methods for treating various …

Methods of treating hypertriglyceridemia

M Manku, I Osterloh, P Wicker, R Braeckman… - US Patent …, 2012 - Google Patents
In various embodiments, the present invention provides methods of treating and/or
preventing cardiovascular-related disease and, in particular, a method of blood lipid therapy …