Androgen deprivation therapy (ADT) and androgen receptor (AR)-targeted therapy are the
gold standard options for treating prostate cancer (PCa). These are initially effective, as …

Akt/PKB is a serine/threonine protein kinase that functions as a critical regulator of cell
survival and proliferation. Akt/PKB family comprises three highly homologous members …

All cancers carry somatic mutations in their genomes. A subset, known as driver mutations,
confer clonal selective advantage on cancer cells and are causally implicated in …

Axonal death disrupts functional connectivity of neural circuits and is a critical feature of
many neurodegenerative disorders. Pathological axon degeneration often occurs …

The Akt serine/threonine kinase (also called protein kinase B) has emerged as a critical
signaling molecule within eukaryotic cells. Significant progress has been made in clarifying …

Protein phosphorylation and dephosphorylation play a major role in intracellular signal
transduction activated by extracellular stimuli. Protein kinase B (PKB/Akt) is a central player …

Background & Aims: Although the natural history and pathologic characteristics of human
hepatocellular carcinoma (HCC) are well documented, the molecular pathogenesis of HCC …

The c-Jun N-terminal kinases (JNKs) are members of a larger group of serine/threonine
(Ser/Thr) protein kinases from the mitogen-activated protein kinase family. JNKs were …

Within the last 15 years, multiple new signal transduction pathways within cells have been
discovered. Many of these pathways belong to what is now termed 'the mitogen-activated …

Signaling pathways control cell fate decisions that ultimately determine the behavior of
cancer cells. Therefore, the dynamics of pathway activity may contain prognostically relevant …