Targeting tumor associated macrophages to overcome conventional treatment resistance in glioblastoma
Glioblastoma (GB) is the most common and devastating form of brain cancer. Despite
conventional treatments, progression or recurrences are systematic. In recent years …
conventional treatments, progression or recurrences are systematic. In recent years …
Glioblastoma multiforme: novel therapeutic targets
Introduction The increasingly detailed genetic characterization of glioblastoma (GBM) has
failed to translate into meaningful breakthroughs in treatment. This is likely to be attributed to …
failed to translate into meaningful breakthroughs in treatment. This is likely to be attributed to …
Single-cell RNA sequencing reveals immunosuppressive myeloid cell diversity during malignant progression in a murine model of glioma
Recent studies have shown the importance of the dynamic tumor microenvironment (TME) in
high-grade gliomas (HGGs). In particular, myeloid cells are known to mediate …
high-grade gliomas (HGGs). In particular, myeloid cells are known to mediate …
Signaling through the inhibitory Fc receptor FcγRIIB induces CD8+ T cell apoptosis to limit T cell immunity
AB Morris, CR Farley, DF Pinelli, LE Adams, MS Cragg… - Immunity, 2020 - cell.com
Effector CD8+ T cells are important mediators of adaptive immunity, and receptor-ligand
interactions that regulate their survival may have therapeutic potential. Here, we identified a …
interactions that regulate their survival may have therapeutic potential. Here, we identified a …
FGL2 promotes tumor progression in the CNS by suppressing CD103+ dendritic cell differentiation
Few studies implicate immunoregulatory gene expression in tumor cells in arbitrating brain
tumor progression. Here we show that fibrinogen-like protein 2 (FGL2) is highly expressed in …
tumor progression. Here we show that fibrinogen-like protein 2 (FGL2) is highly expressed in …
[HTML][HTML] The role of Fibrinogen-like proteins in Cancer
J Yu, J Li, J Shen, F Du, X Wu, M Li… - … journal of biological …, 2021 - ncbi.nlm.nih.gov
Fibrinogen-associated protein (FREP) family is a family of proteins with a fibrin domain at the
carboxyl terminus. Recent investigations illustrated that two members of FREP family …
carboxyl terminus. Recent investigations illustrated that two members of FREP family …
FGL2-targeting T cells exhibit antitumor effects on glioblastoma and recruit tumor-specific brain-resident memory T cells
Although tissue-resident memory T (TRM) cells specific for previously encountered
pathogens have been characterized, the induction and recruitment of brain TRM cells …
pathogens have been characterized, the induction and recruitment of brain TRM cells …
FGL2-wired macrophages secrete CXCL7 to regulate the stem-like functionality of glioma cells
Glioma stem cells (GSCs) are thought to underlie glioma initiation, evolution, resistance to
therapies, and relapse. They are defined by their capacity to initiate glioma in …
therapies, and relapse. They are defined by their capacity to initiate glioma in …
[HTML][HTML] Fibrinogen-like protein 2 in inflammatory diseases: a future therapeutic target
L Fu, Z Liu, Y Liu - International Immunopharmacology, 2023 - Elsevier
Abstract Fibrinogen-like protein 2 (FGL2), a member of the fibrinogen family, exists as a
membrane-bound protein with immune-associated coagulation activity and a soluble form …
membrane-bound protein with immune-associated coagulation activity and a soluble form …
Tumor-associated macrophage polarization promotes the progression of esophageal carcinoma
X Yuan, Y Li, AZ Zhang, CH Jiang, FP Li… - Aging (Albany …, 2020 - pmc.ncbi.nlm.nih.gov
The immune response facilitated by tumor-associated macrophages is a vital determinant of
tumor progression. We identified differentially expressed genes between various …
tumor progression. We identified differentially expressed genes between various …