Phosphoinositides (PIs) make up only a small fraction of cellular phospholipids, yet they
control almost all aspects of a cell's life and death. These lipids gained tremendous research …

Phosphatidylinositol, a component of eukaryotic cell membranes, is unique among
phospholipids in that its head group can be phosphorylated at multiple free hydroxyls …

Autophagy is a lysosome-based degradation pathway. During autophagy, lysosomes fuse
with autophagosomes to form autolysosomes. Following starvation-induced autophagy …

Abstract Synthesis of phosphatidylinositol 4, 5-bisphosphate [PI (4, 5) P 2], a signaling
phospholipid, is primarily carried out by phosphatidylinositol 4-phosphate 5-kinase [PI (4) …

Abstract Phosphatidylinositol-4, 5-bisphosphate (PtdIns-4, 5-P2), a key molecule in the
phosphoinositide signalling pathway, was thought to be synthesized exclusively by …

Phosphoinositides are lipids that are present in the cytoplasmic leaflet of a cell's plasma and
internal membranes and play pivotal roles in the regulation of a wide variety of cellular …

The Saccharomyces cerevisiae FAB1 gene encodes a 257-kD protein that contains a
cysteine-rich RING-FYVE domain at its NH2-terminus and a kinase domain at its COOH …

1.1. Background Beginning in the early 1980s, cell biologists started realising that some
phospholipids are not just basic constituents of membranes but dynamic informational …

▪ Abstract Signaling roles for phosphoinositides that involve their regulated hydrolysis to
generate second messengers have been well characterized. Recent work has revealed …

It is now well appreciated that derivatives of phosphatidylinositol (PtdIns) are key regulators
of many cellular processes in eukaryotes. Of particular interest are phosphoinositides (mono …