Cardiac glycosides are a diverse family of naturally derived compounds that bind to and
inhibit Na+/K+-ATPase. Members of this family have been in clinical use for many years for …

Conventional chemotherapeutic agents are often toxic not only to tumor cells but also to
normal cells, limiting their therapeutic use in the clinic. Novel natural product anticancer …

There is a growing need for biocompatible click reactions in order to prepare multifunctional
conjugates, which are valuable molecules for innovative biomedical applications. In this …

Covering: up to 2012 Steroids, a widespread class of natural organic compounds occurring
in animals, plants and fungi, have shown great therapeutic value for a broad array of …

Many biologically active small‐molecule natural products produced by microorganisms
derive their activities from sugar substituents. Changing the structures of these sugars can …

The sodium pump, Na+/K+-ATPase, could be an important target for the development of anti-
cancer drugs as it serves as a versatile signal transducer, it is a key player in cell adhesion …

Covering: up to the end of May 2011 Glyco (randomization/diversification) is a term that
encompasses strategies to diversify a core drug scaffold via enzymatic glycosylation to …

Ginseng has a prominent position on the list of best-selling herbal products in the world, and
its main active constituents are thought to be ginsenosides. Compared with the long history …

Cardiotonic steroids (CTSs) are ancient and effective clinical drugs for treating heart failure.
Glycosylation of the CTS, especially at the C-3 position, is of great significance in nowadays …

The efficient and stereoselective construction of glycosidic linkages remains one of the most
formidable challenges in organic chemistry. This is especially true in cases such as β-linked …