The viscoelastic mucus secretions coating exposed organs such as the lung airways and the
female reproductive tract can trap and quickly eliminate not only foreign pathogens and …

Polyethylenimine (PEI) has recently been widely studied for the design of nucleic acid
delivery vehicles. Gene delivery using PEI involves condensation of DNA into compact …

Gene therapy has become a promising strategy for the treatment of many inheritable or
acquired diseases that are currently considered incurable. Non-viral vectors have attracted …

The continually increasing wealth of knowledge about the role of genes involved in acquired
or hereditary diseases renders the delivery of regulatory genes or nucleic acids into affected …

No Heading Polymeric gene delivery systems have been developed as an alternative for
viral gene delivery systems to overcome the problems in the use of viral gene carriers …

Inhaled gene carriers must penetrate the highly viscoelastic and adhesive mucus barrier in
the airway in order to overcome rapid mucociliary clearance and reach the underlying …

Tumor-targeting DNA complexes which can readily be generated by the mixing of stable
components and freeze− thawed would be very advantageous for their subsequent …

Branched and linear polyethylenimines (PEIs) have proven to be efficient and versatile
agents for gene delivery in vitro. In addition, systemic administration of positively charged …

Surface-shielded DNA delivery systems have been synthesized with virus-like
characteristics that target gene expression into distant tumor tissues. Polyethylenimine …

The influence of PEGylation on polyplex stability from poly (ethylene imine), PEI, and
plasmid DNA was investigated both in vitro and after intravenous administration in mice …